Sort   by:  
 Page size 
GenomicsCpG island-mediated global gene regulatory modes in mouse embryonic stem cells
In order to identify the regions occupied by transcription factors, we performed bio-ChIP followed by massive parallel sequencing (bioChIP-Seq) in mouse ES cells. A total of seven DNA transcription factors including Myc module (Myc, Max, E2F4, Tip60 and Dmap1) and Core module transcription factors (...
ORGANISM(S): Mus musculus 
2014-11-24 | E-GEOD-48666 | biostudies-arrayexpress
UnknownMultiple strategies to prevent oxidative stress in Arabidopsis plants lacking the malate valve enzyme NADP-malate dehydrogenase.
Not available
S-EPMC3276105 | biostudies-literature
MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria: secreted metabolite analysis for resting cells (B.uniformis;C.saccharolyticum assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1757 | MetaboLights
TranscriptomicsB-type lamins differentially associate with specific genes during differentiation without directly affecting their expression
B-type lamins, the major structural component of the nuclear lamina, is thought to play a repressive role in the expression of many of its bound genes whose silencing are known to be critical for cell differentiation during early development. Using global mapping of lamin-B-chromatin interaction, w...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-24532 | biostudies-arrayexpress
TranscriptomicsAging-induced differential methylation in human PBMCs occurs with but often without change in expression of the associated gene (DNA Methylation)
Aging is a progressive process that results in the accumulation of intra- and extracellular alterations that in turn contribute to a reduction in health. Age-related changes in DNA methylation have been reported before and may be responsible for aging-induced changes in gene expression, although a c...
ORGANISM(S): Homo sapiens 
2014-05-09 | E-GEOD-49064 | biostudies-arrayexpress
ProteomicsSnapshot of in-cell protein contact sites reveals new host factors and hijacking of paraspeckles during influenza A virus infection
Influenza A virus (IAV) hijacks host cellular machinery, but many virus–IAV interactions and contacting protein sites remain uncharacterised, particularly those dependent on intact cellular architecture, such as membrane-associated or phase- separated compartments. Here, we applied in-cell cross-lin...
ORGANISM(S): Homo sapiens (Human) Influenza A virus (A/WSN/1933(H1N1)) 
2026-04-23 | PXD071226 | Pride
Bioorthogonal labeling Influenza a virus Cross-linking mass spectrometry Affinity purification mass spectrometry 
TranscriptomicsAging-induced differential methylation in human PBMCs occurs with but often without change in expression of the associated gene (Expression)
Aging is a progressive process that results in the accumulation of intra- and extracellular alterations that in turn contribute to a reduction in health. Age-related changes in DNA methylation have been reported before and may be responsible for aging-induced changes in gene expression, although a c...
ORGANISM(S): Homo sapiens 
2014-05-09 | E-GEOD-49058 | biostudies-arrayexpress
TranscriptomicsAging-induced differential methylation in human PBMCs occurs with but often without change in expression of the associated gene
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-05-09 | E-GEOD-49065 | biostudies-arrayexpress
ProteomicsArabidopsis thaliana Col-0 wild type, deg10-1, deg10-2 and catr3-1 root proteome
Deg/HtrA proteases are important factors of the cellular protein quality control system, but little is know about their function in mitochondria. DEG10 loss-of-function mutants were impaired in root elongation at elevated temperature and reduced seed set in field trials. This study analysed the root...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-06-06 | PXD007204 | Pride
Roots Arabidopsis Protease Mitochondria Deg10 
MetabolomicsOperation of a TCA cycle subnetwork in the mammalian nucleus

Nucleic acid and histone modifications critically depend on tricarboxylic acid (TCA) cycle for substrates and co-factors. Although a few TCA cycle enzymes have been reported in the nucleus, the corresponding pathways are considered to operate in mitochondria. Here, we show that a part of the...

2022-06-15 | MTBLS2235 | MetaboLights
Sort   by:  
 Page size