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GenomicsMethylome Analysis of FF HPV+ and HPV- HNSCC samples
The analysis of the 6 methylomes by MeDIP-Seq comprise 3 HPV+ HNSCC samples and 3 HPV- HNSCC samples Analysis of the 6 methylomes, comprising 3 HPV+ HNSCC samples and 3 HPV- HNSCC samples
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-38263 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of human placenta, sperm, liver and CD8+ T cells using a genomic tiling array
We have generated and validated a genomic tiling array that can be used to analyse genetic and epigenetic features of the MHC. We demonstrated its utility for DNA methylation profiling and the identification of tDMRs. Based on our experience, we expect the array to be suitable for a number of assays...
ORGANISM(S): Homo sapiens 
2008-09-08 | E-TABM-471 | biostudies-arrayexpress
GenomicsComparative methylome analysis of benign and malignant peripheral nerve sheath tumors
Aberrant DNA methylation (DNAm) was first linked to cancer over 25 years ago. Since then, many studies have associated hypermethylation of tumour suppressor genes and hypomethylation of oncogenes to the tumourigenic process. However, most of these studies have been limited to the analysis of promote...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-21714 | biostudies-arrayexpress
TranscriptomicsExpression data for human epithelium from subjects with atopic dermatitis, psoriasis and nonatopic controls
The expression and function of tight junction genes, in particular claudin-1, was studied in order to further understanding of the biology underlying atopic dermatitis. Gene expression profiling was performed on total RNA from nonlesional epidermal samples from 5 subjects with atopic dermatitis, 4 s...
ORGANISM(S): Homo sapiens 
2011-01-29 | E-GEOD-26952 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of human first and thrid trimester placenta and whole blood
Fifteen DNA methylation array experiments were performed on five human chromosome specific array platforms (NimbleGen: HG18_CHR13_FT, HG18_CHR18_FT, HG18_CHR21_FT, HG18_CHRX_FT, HG18_CHRY_FT), comparing: (1) one female whole blood immunoprecipitated DNA fragments to their input DNA, (2) one 1st tri...
ORGANISM(S): Homo sapiens 
2009-05-01 | E-TABM-507 | biostudies-arrayexpress
TranscriptomicsHumanMethylation450 (450k) data for 79 rheumatoid arthritis disease discordant monozygotic twin pairs
This project contains genome-wide DNA methylation data generated using the HumanMethylation450 BeadChip (Illumina), for 79 rheumatoid arthritis (RA) discordant monozygotic twin pairs. By investigating disease discordant monozygotic twins, DNA methylation can be assessed without the confounding influ...
ORGANISM(S): Homo sapiens 
2018-07-24 | E-MTAB-6988 | biostudies-arrayexpress
ProteomicsProteomics of tumor associated microglia, tumor tissue from SB28 glioblastoma mice, and control microglia
The 18 kDa translocator protein (TSPO) emerges as an important PET biomarker to assess the tumor microenvironment (TME) in glioblastoma. However, various cellular sources hamper interpretation and biological understanding of TSPO and other immune biomarkers in the TME. Thus, we established a novel m...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-30 | PXD044033 | Pride
Tumor tissue Microglia Tumor associated microglia Sb28 glioblastoma 
TranscriptomicsExpression profiling of glioblastoma neural stem cells and reprogrammed derivatives
Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Gene expression profiling was performed in comparison to normal neural stem (NS) cells reprogrammed in parallel, as well as standard ES cells as an indepe...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-MTAB-1273 | biostudies-arrayexpress
TranscriptomicsHigh-resolution methylation profiling of glioblastoma neural stem cells and reprogrammed derivatives
Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Genome-wide DNA methylation status was profiled at 485,000 loci to assess epigenetic erasure and restoration due to reprogramming and redifferentiation to...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-MTAB-1271 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of glioblastoma neural stem cells and reprogrammed derivatives
Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Genome-wide DNA methylation status was profiled at 27,578 CpG sites to assess epigenetic erasure and restoration due to reprogramming and redifferentiatio...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-MTAB-1275 | biostudies-arrayexpress
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