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TranscriptomicsWnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.
We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy designed to target the BRAF(V600E) mutation in melanoma. Here, we show that melanomas characterized by high levels of Wnt5A respond to therapeutic stress by increasing p21 an...
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-50004 | biostudies-arrayexpress
TranscriptomicsStimulation of Human and Rat Islet β-Cell Proliferation with Retention of Function by Nkx6.1
The homeodomain transcription factor Nkx6.1 plays an important role in pancreatic islet β-cell development, but its effects on adult β-cell function, survival, and proliferation are not well understood. In the present study, we demonstrated that treatment of primary rat pancreatic islets with a cy...
ORGANISM(S): Rattus norvegicus 
2010-05-18 | E-GEOD-13153 | biostudies-arrayexpress
TranscriptomicsMultiple functions for Eya3 in mammalian organism
The important function of Eya (eyes absent) in eye development of D.melanogaster is well known, the function of its mammalian orthologs Eya1-4 is only partially understood. Yet, no phenotype for Eya2 and Eya3 in humans or mouse have been described. In our study we analysed new Eya-deficient mouse m...
ORGANISM(S): Mus musculus 
2008-12-17 | E-GEOD-9999 | biostudies-arrayexpress
TranscriptomicsArray profiling of dystrophin-deficient mice with a secondary glycosylation defect
A deletion in the CMAH gene in humans occurred approximately 3.5 million years ago. This resulted in the inactivation of the CMP-Neu5Ac hydroxylase enzyme, and hence, in the specific deficiency in N-glycolylneuraminic acid (Neu5Gc), a form of sialic acid, in all modern humans. Although there is evid...
ORGANISM(S): Mus musculus 
2010-07-31 | E-GEOD-16438 | biostudies-arrayexpress
TranscriptomicsscRNAseq of her4.3+ cells from lesioned and unlesioned zebrafish larvae spinal cord
To analyse lesion-induced gene regulation in progenitor cells at single cell resolution, we performed single cell RNAseq on FACS-isolated her4.3:GFP progenitor cells from the spinal cord at 24 hours post-lesion (hpl) after spinal injury at 3 days post-fertilisation (dpf), compared to age-matched uni...
ORGANISM(S): Danio rerio 
2021-05-24 | E-MTAB-10390 | biostudies-arrayexpress
TranscriptomicsscRNAseq of mpeg1.1+ cells from lesioned and unlesioned zebrafish larvae spinal cord
To analyse lesion-induced gene regulation in macrophage and microglia at single cell resolution, we performed single cell RNAseq on FACS-isolated mpeg1.1:GFP cells from the spinal cord at 24 hours post-lesion (hpl) after spinal injury at 3 days post-fertilisation (dpf), compared to age-matched uninj...
ORGANISM(S): Danio rerio 
2021-05-24 | E-MTAB-10379 | biostudies-arrayexpress
UnknownWnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.
Not available
S-EPMC4333017 | biostudies-literature
UnknownVericiguat: A Randomized, Phase Ib, Placebo-Controlled, Double-Blind, QTc Interval Study in Patients with Chronic Coronary Syndromes.
Not available
S-EPMC10006255 | biostudies-literature
UnknownAssociation between COVID-19 vaccination and progression to severe outcomes in hospitalized COVID-19 patients in Hungary during the pre-Omicron era of the COVID-19 pandemic.
Not available
S-EPMC12494597 | biostudies-literature
UnknownGenome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up.
Not available
S-EPMC5443897 | biostudies-literature
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