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TranscriptomicsThe SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
The prevention or delay of the onset of age-related diseases prolongs survival and improves quality of life while reducing the burden on the health care system. Activation of sirtuin 1 (SIRT1), an NAD+ deacetylase, improves metabolism and confers protection against physiological and cognitive distur...
ORGANISM(S): Mus musculus 
2014-12-20 | E-GEOD-50987 | biostudies-arrayexpress
UnknownMetabolic and molecular framework for the enhancement of endurance by intermittent food deprivation.
Not available
S-EPMC5998977 | biostudies-literature
UnknownIn-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy.
Not available
S-EPMC8131353 | biostudies-literature
TranscriptomicsIdentification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach.
Employing MCT-1 oncogene mediated transformation of immortalized breast epithelial MCF10A cells; we characterized the largely reciprocal association of these two RBPs with target mRNAs and their influence on protein expression vis-à-vis cellular transformation. Using a ribonomics approach, we ident...
ORGANISM(S): Homo sapiens 
2008-07-29 | E-GEOD-12215 | biostudies-arrayexpress
TranscriptomicsSRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
Increased expression of SIRT1 extends the lifespan of lower organisms and delays the onset of age-related diseases in mammals. Here, we show that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improve...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-49000 | biostudies-arrayexpress
TranscriptomicsExendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice
Traumatic brain injury (TBI) is a global problem reaching near epidemic numbers that manifests clinically with cognitive problems that decades later may result in dementias like Alzheimer’s disease (AD). Presently, little can be done to prevent ensuing neurological dysfunctions by pharmacological me...
ORGANISM(S): Mus musculus 
2012-10-17 | E-GEOD-41345 | biostudies-arrayexpress
UnknownA Phase 1, Double-Blind, Placebo-Controlled Trial of Sevasemten (EDG-5506), a Selective Modulator of Fast Skeletal Muscle Contraction, in Healthy Volunteers and Adults With Becker Muscular Dystrophy.
Not available
S-EPMC12338012 | biostudies-literature
TranscriptomicsRNA-binding protein AUF1 promotes myogenesis by regulating MEF2C expression levels
The mammalian RNA-binding protein AUF1 (AU-binding factor 1, also known as heterogeneous nuclear ribonucleoprotein D, hnRNP D) binds to numerous mRNAs and influences their post-transcriptional fate. Given that many AUF1 target mRNAs encode muscle-specific factors, we investigated the function of AU...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-58259 | biostudies-arrayexpress
TranscriptomicsChanges in mouse cognition and hippocampal gene expression observed in a mild physical- and blast-traumatic brain injury
Warfare has long been associated with traumatic brain injury (TBI) in militarized zones. Common forms of TBI can be caused by a physical insult to the head-brain or by the effects of a high velocity blast shock wave generated by the detonation of an explosive device. While both forms of trauma are d...
ORGANISM(S): Mus musculus 
2013-03-18 | E-GEOD-44625 | biostudies-arrayexpress
UnknownEnhanced translation by Nucleolin via G-rich elements in coding and non-coding regions of target mRNAs.
Not available
S-EPMC3201861 | biostudies-literature
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