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MetabolomicsFDR-controlled metabolite annotation for high-resolution imaging mass spectrometry imaging MS (LC-MS assay)
High-mass-resolution imaging mass spectrometry promises to localize hundreds of metabolites directly from tissues, cell cultures, and agar plates with cellular resolution, but is hampered by the lack of bioinformatics for automated metabolite identification. We developed the first bioinformatics fra...
2016-12-05 | MTBLS378 | MetaboLights
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (MS assays)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS674 | MetaboLights
MetabolomicsFDR-controlled metabolite annotation for high-resolution imaging mass spectrometry imaging MS (MALDI imaging assay)
High-mass-resolution imaging mass spectrometry promises to localize hundreds of metabolites directly from tissues, cell cultures, and agar plates with cellular resolution, but is hampered by the lack of bioinformatics for automated metabolite identification. We developed the first bioinformatics fra...
2017-04-10 | MTBLS313 | MetaboLights
MetabolomicsFDR-controlled metabolite annotation for high-resolution imaging mass spectrometry - simulated Imaging MS (Imaging simulation assay)
High-mass-resolution imaging mass spectrometry promises to localize hundreds of metabolites directly from tissues, cell cultures, and agar plates with cellular resolution, but is hampered by the lack of bioinformatics for automated metabolite identification. We developed the first bioinformatics fra...
2016-12-05 | MTBLS317 | MetaboLights
ProteomicsInteractions between basic helix-loop-helix transcription factors and nucleosomes
In solution crosslinking mass spectrometry of transcription factors in complex with nucleosomes
ORGANISM(S): Homo sapiens (Human) 
2023-05-23 | PXD033181 | Pride
Dsso crosslinking xlinkx pd transcription factor nucleosome human 
MetabolomicsBenchmark datasets for 3D MALDI- and DESI-Imaging Mass Spectrometry
Three-dimensional imaging mass spectrometry (3D imaging MS) is a technique of analytical chemistry for 3D molecular analysis of a tissue specimen, entire organ, or microbial colonies on an agar plate. 3D imaging MS has unique advantages over existing 3D imaging techniques, offers novel perspectives ...
2016-07-27 | MTBLS176 | MetaboLights
TranscriptomicsEnhanced upregulation of CRH mRNA expression in the rat nucleus accumbens after a delayed second injection of methamphetamine
Methamphetamine (METH) is a widely abused illicit amphetamine that causes acute biochemical and molecular changes in the brain. However, there are very few studies that have investigated the long-term effects of a single METH exposure in adult animals. The purpose of this study was thus to determin...
ORGANISM(S): Rattus norvegicus 
2013-06-30 | E-GEOD-46717 | biostudies-arrayexpress
GenomicsGenome-wide analysis of acetylated H4K5 binding offers new insights into the acute and chronic effects of METH on gene expression in the dorsal striatum
In contrast to the acute METH-induced transcriptional changes, chronic METH administration produces differential changes in IEG responses and blunts the striatal effects of a single METH injection (McCoy et al., 2011). These observations suggested that chromic METH might have caused changes in the m...
ORGANISM(S): Rattus norvegicus 
2013-02-28 | E-GEOD-42776 | biostudies-arrayexpress
ProteomicsA renal function for 2,3-bisphosphoglycerate mutase (BPGM)
The enzyme 2,3 bisphosphoglycerate mutase (BPGM) catalyzes the production of 2,3-bisphosphoglycerate (2,3-BPG). The main role of 2,3-BPG is to shift the equilibrium of hemoglobin toward the deoxy-state, accounting for the notion that 2,3-BPG production would appear to be solely useful in cells which...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD033095 | Pride
Metabolism Nephron Reactive oxygen species (ros) Kidney Bpgm Acute kidney injury (aki) Apoptosis 
ProteomicsGalleria mellonella immune response to infection with Streptococcus pyogenes
The larvae of Galleria mellonella are increasingly popular as infection model organism to study virulence mechanisms and pathogenicity of bacteria and fungi. In this study, the Streptococcus pyogenes-specific immune response of the larvae was investigated using a proteomics approach. Larvae of the g...
ORGANISM(S): Galleria mellonella 
2025-10-06 | PXD054400 | Pride
Streptococcus pyogenes Immune response Galleria mellonella Infection model organism Insect infection model Infection Proteome 
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