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UnknownMeasurements for 8 common analytes in native sera identify inadequate standardization among 6 routine laboratory assays.
Not available
S-EPMC5699466 | biostudies-literature
TranscriptomicsMicroRNA-520c-3p targets eIF4GII and acts as a tumor suppressor in diffuse large B cell lymphoma
Deregulation of the translational machinery is emerging as a critical contributor to lymphomagenesis. Various miRNA alterations have been identified in lymphoma, but their role in disrupting the cap-dependent translation regulation complex remains poorly understood. Here, we demonstrate the translat...
ORGANISM(S): Homo sapiens 
2014-03-19 | E-GEOD-40489 | biostudies-arrayexpress
GenomicsEpigenetic profiling of well differentiated and dedifferentiated liposarcoma identifies H3K9me3 and Kruppel-like factor 6 (KLF6) as determinants of aggressiveness in sarcoma (ChIP-seq)
Little is known about the epigenomics of liposarcoma (LPS). Here, we profiled the global expression of 9 epigenetic marks in well differentiated (WD) and dedifferentiated (DD) LPS from 151 patients and found increased H3K9me3 among DDLPS tumors. We performed ChIP-seq and gene expression profiling ...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-57749 | biostudies-arrayexpress
TranscriptomicsDe Novo Assembly and Characterization of Stress Transcriptome in a salinity-Tolerant Variety CS52 of Brassica juncea
Oilseed mustard, Brassica juncea, exhibits high levels of genetic variability for salinity tolerance. To obtain the global view of transcriptome and investigate the molecular basis of salinity tolerance in a salt-tolerant variety CS52 of B. juncea, we performed transcriptome sequencing of control an...
ORGANISM(S): Brassica juncea 
2015-02-28 | E-GEOD-66389 | biostudies-arrayexpress
TranscriptomicsRB is a cell cycle-regulated repressor of cohesin-dependent loop formation
Chromatin organization and cell cycle are tightly intertwined in eukaryotes, but the underlying mechanisms remain unclear. We investigated how the retinoblastoma protein (RB), a key cell cycle regulator, influences chromatin architecture. Chromosome conformation capture assays reveal that RB loss in...
ORGANISM(S): Homo sapiens 
2024-11-01 | E-MTAB-13566 | biostudies-arrayexpress
UnknownEpigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort.
Not available
S-EPMC4890596 | biostudies-literature
TranscriptomicsTwo Lysines in the Forkhead Domain of Foxp3 are Key to T Regulatory Cell Function
The forkhead transcription factor, Foxp3, is pivotal to the development and function of CD4+CD25+ T regulatory (Treg) cells that limit autoimmunity and maintain immune homeostasis. Previous data indicated that many of the functions of Foxp3 are controlled by the acetylation of several lysines within...
ORGANISM(S): Mus musculus 
2011-02-05 | E-GEOD-27082 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain from animals treated with cocaine vs controls
Several recent reports show that the cerebral cortex in humans and animals with altered expressions of Wnt/cadherin network-associate molecules display cytoarchitectural abnormalities reminiscent of cortical dysplasias seen in some (mouse-, rat-, and monkey-based) animal models of prenatal cocaine e...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6628 | biostudies-arrayexpress
TranscriptomicsHDAC6 and HSP90 control the functions of Foxp3+ T regulatory cells
Foxp3+ T-regulatory cells (Tregs) are key to immune homeostasis such that their diminished numbers or function can cause autoimmunity and allograft rejection. Foxp3+ Tregs express histone/protein deacetylases (HDACs) that regulate chromatin remodeling, gene expression and protein function. Pan-HDAC ...
ORGANISM(S): Mus musculus 
2011-05-01 | E-GEOD-27896 | biostudies-arrayexpress
TranscriptomicsThe role of antigen presenting cells in the induction of HIV-1 latency in resting CD4+ T-cells
BACKGROUND: Combination antiretroviral therapy (cART) is able to control HIV-1 viral replication, however long-lived latent infection in resting memory CD4+ T-cells persist. The mechanisms for establishment and maintenance of latent infection in resting memory CD4+ T-cells remain unclear. Previously...
ORGANISM(S): Homo sapiens 
2015-12-23 | E-GEOD-70106 | biostudies-arrayexpress
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