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ProteomicsTherapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury
Background: Ischemia-reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the build-up of acidic metabolites results in decreased intracellular and extracellular pH that can reach as low as 6....
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-11-01 | PXD024581 | Pride
Heart Venom Mass spectrometry Therapeutic Human induced pluripotent stem cells Ischemia-reperfusion injury 
ProteomicsMulti-omics of a pre-clinical model of diabetic cardiomyopathy reveals increased fatty acid supply impacts mitochondrial metabolic selectivity
The incidence of type 2 diabetes (T2D) is increasing globally, with long-term implications for human health and longevity. Heart disease is the leading cause of death in T2D patients, who display an elevated risk of an acute cardiovascular event and worse outcomes following such an insult. The under...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-11-01 | PXD029587 | Pride
Heart Proteomics Multiomics Diabetic cardiomyopathy 
ProteomicsResponse of C. jejuni to various environmental conditions
Campylobacter jejuni is the leading cause of foodborne human gastroenteritis in the developed world. Infections are largely acquired from poultry produced for human consumption and poor food handling is thus a major risk factor. In this study, C. jejuni were exposed to growth in a number of enviornm...
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Bacteria 
2024-06-23 | PXD051724 | Pride
Deferroxamine Deoxycholate Chicken exudate Campylobacter 
TranscriptomicsMouse feeding experiment
Mice used in this study were 129/sv males, 8-15 weeks of age, which were housed individually and received water ad libitum. Normal fed animals were fed before and during the 48h experiment with standard food ad libitum. Sugar fed animals were fed before the experiment with standard food ad libitum a...
ORGANISM(S): Mus musculus 
2004-02-08 | E-GEOD-858 | biostudies-arrayexpress
UnknownDisruption of the ASTN2/TRIM32 locus at 9q33.1 is a risk factor in males for autism spectrum disorders, ADHD and other neurodevelopmental phenotypes.
Not available
S-EPMC3990173 | biostudies-literature
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