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The accumulation of senescent cells constitutes a pivotal hallmark of tissue ageing, contributing to disruption of tissue homeostasis and thus, to the development of several aging-related diseases. We employ transcriptomics (alongside proteomics) to determine changes at the mRNA and protein levels, ...
ORGANISM(S): Homo sapiens 
Autophagy is responsible for degradation of an extensive portfolio of cytosolic cargoes that are engulfed in autophagosomes to facilitate their transport to lysosomes. Besides basal autophagy, which constantly degrades cellular material, the pathway is dynamically altered by different conditions, re...
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD024419 | Pride
The metalloproteinase ovastacin is released by the mammalian oocyte upon fertilization and cleaves zona pellucida protein 2, a component of the surrounding extracellular matrix, at a distinct cleavage site. This limited proteolysis hardens the zona pellucida, abolishes sperm binding and thereby regu...
ORGANISM(S): Mus Musculus (mouse) 
Bag3 and MVP regulate apoptosis resistance in Therapy Induced Senescence (TIS)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079929 | MassIVE
Bag3 and MVP regulate apoptosis resistance in Therapy Induced Senescence (TIS)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079932 | MassIVE
Bag3 and MVP regulate apoptosis resistance in Therapy Induced Senescence (TIS)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079924 | MassIVE
Bag3 and MVP regulate apoptosis resistance in Therapy Induced Senescence (TIS)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079930 | MassIVE
Bag3 and MVP regulate apoptosis resistance in Therapy Induced Senescence (TIS)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079989 | MassIVE
Bag3 and MVP regulate apoptosis resistance in Therapy Induced Senescence (TIS)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079931 | MassIVE
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