Sort   by:  
 Page size 
ProteomicsBrain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
Supporting TMT MS data for paper (doi: 10.1016/j.neuron.2021.12.029) by Goldsmith J. et al., titled "Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons". Index of RAW files uploaded: AO3068-3079: Fractionated (12 fr...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-08-01 | MSV000092565 | MassIVE
MetabolomicsQuantification of PIPs species in mouse embryonic fibroblasts (MEFs) during autophagosome formation.
Not available
ORGANISM(S): Mus musculus 
ST001818 | MetabolomicsWorkbench
TranscriptomicsTranscriptional regulation by Pho23 modulates the frequency of autophagosome formation.
Autophagy as a conserved degradation and recycling machinery is important in normal development and physiology, and defects in this process are linked to many kinds of disease. Because too much or too little autophagy can be detrimental, the process must be tightly regulated both temporally and in m...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-24 | E-GEOD-57031 | biostudies-arrayexpress
GenomicsA lysosomal delivery mechanism required for autophagosome degradation
A lysosomal delivery mechanism required for autophagosome degradation
PRJEB62651 | ENA
GenomicsExamination of hepatic SREBP-2 binding using ChIP-Seq
Sterol regulatory element binding proteins (SREBPs) are key transcriptional regulators of lipid metabolism. To define functional differences between the three mammalian SREBPs we are using genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-28082 | biostudies-arrayexpress
ProteomicsThe V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation
Autophagy is a finely orchestrated process required for the lysosomal degradation of cytosolic components. The final degradation step is essential for clearing autophagic cargo and recycling macromolecules. Using a CRISPR/Cas9-based screen, we identify RNAseK, a highly conserved transmembrane protei...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-02 | PXD042079 | Pride
Dia-ms Autophagosome degradation Rnasek Lysosome 
ProteomicsSNAP47 acetylation-dependent regulatory mechanism governing autophagosome-lysosome fusion by modulating the recruitment of HOPS to autophagic vacuoles
Autophagy, a conserved catabolic process implicated in a diverse array of human diseases, requires efficient fusion between autophagosomes and lysosomes to function effectively. Recently, SNAP47 has been identified as a key component of the default SNARE complex mediating autophagosome-lysosome fusi...
ORGANISM(S): Homo Sapiens 
PXD052239 |
ProteomicsThe Plant Unique ESCRT Component FREE1 Regulates Autophagosome Closure
The energy sensor AMP-activated protein kinase (AMPK) can activate autophagy when cellular energy production becomes compromised. However, the degree to which nutrient sensing impinges on the autophagosome closure remains unknown. Here, we provide the mechanism underlying a plant unique protein FREE...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-03-30 | PXD040435 | Pride
Ap-ms Autophagosome Arabidopsis thaliana Escrt Free1 
ProteomicsA lysosomal delivery mechanism required for autophagosome degradation
Autophagy is a finely orchestrated process required for the lysosomal degradation of cytosolic components. The final degradation step is essential for clearing autophagic cargo and recycling macromolecules. We identified a highly conserved transmembrane protein named RNAseK as a novel regulator of a...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-05 | PXD042727 | Pride
Autophagy 
UnknownMeasuring autophagosome flux.
Not available
S-EPMC6103398 | biostudies-literature
Sort   by:  
 Page size