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ProteomicsEnhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing
Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassemia or sickle cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level of minor blood group antigens. We use CRISPR-mediated genome ...
ORGANISM(S): Homo sapiens (Human) 
2018-04-26 | PXD009291 | Pride
Erythroid Blood Crispr Bel-a. transfusion Universal donor 
GenomicsABO c.28+3insT
A novel splice- site mutation in the ABO gene causing an ABO Bel subgroup phenotype
PRJEB35433 | ENA
UnknownEnhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing.
Not available
S-EPMC5991592 | biostudies-literature
UnknownTwo novel mutations p. L319V and p. L91P in ABO glycosyltransferases lead to Ael and Bel phenotypes.
Not available
S-EPMC7605879 | biostudies-literature
UnknownA Novel Mutation Eliminates GATA-1 and RUNX1-Mediated Promoter Activity in Galactosyltransferase Gene.
Not available
S-EPMC9768290 | biostudies-literature
Transcriptomics5' Cap-Isolated RNA Pol II Transcripts and ENCODE Tiling Arrays to Identify Gene Expression Changes in Hepatitis C Liver
Recent studies of the human transcriptome suggest that many transcripts have short or lack 3' poly(A) ends. In addition, the length of 3' poly(A) ends may vary for some transcript to regulate mRNA translation. Heterogeneous lengths of poly(A) ends may introduce variations in measuring RNA transcript...
ORGANISM(S): Homo sapiens 
2011-03-29 | E-GEOD-18904 | biostudies-arrayexpress
UnknownDisruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype.
Not available
S-EPMC7366909 | biostudies-literature
TranscriptomicsPolysome profiling of Huh7.5 cells expressing HCV NS5A
Hepatitis C Virus protein NS5A was found to upregulate assembly of cap binding initiation complex eIF4F in Huh7.5 cells. NS5A also was found to associate with translation machinery. To understand consequences of NS5A mediation in host translation, we analyzed mRNA associated with polysome fractions ...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-46273 | biostudies-arrayexpress
UnknownSix splice site variations, three of them novel, in the ABO gene occurring in nine individuals with ABO subtypes.
Not available
S-EPMC8607603 | biostudies-literature
UnknownAssociation between CASP8 -652 6N del polymorphism (rs3834129) and colorectal cancer risk: results from a multi-centric study.
Not available
S-EPMC3897464 | biostudies-literature
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