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GenomicsH3K4 tri-methylation provides an epigenetic signature of active enhancers
Combinations of post-translational histone modifications shape the chromatin landscape during cell development in eukaryotes. However, little is known about the modifications exactly delineating functionally engaged regulatory elements. For example, although histone H3 lysine 4 mono-methylation (H3K...
ORGANISM(S): Mus musculus 
2014-03-07 | E-GEOD-55635 | biostudies-arrayexpress
TranscriptomicsThe TCR activation acts as a tumor suppressor mechanism in T-ALL
Developmental checkpoints in stem/progenitor cells are critical to the determination, commitment and differentiation into distinct lineages. Cancer cells often retain expression of lineage-specific checkpoint proteins, but their potential impact in cancer remains elusive. T lymphocytes mature in the...
ORGANISM(S): Homo sapiens 
2016-08-20 | E-GEOD-65496 | biostudies-arrayexpress
TranscriptomicsLong-range bidirectional transcription is a general feature of developmental gene promoters in mammals (RNA-Seq 2)
Recent studies have revealed a myriad of non-coding transcripts in different organisms. For instances, the presence of short bidirectional transcripts is a hallmark of active promoters in mammals, while upstream non-coding transcripts can be detected at most expressed genes in conditions where the R...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-44575 | biostudies-arrayexpress
TranscriptomicsLong-range bidirectional transcription is a general feature of developmental gene promoters in mammals (RNA-Seq 1)
Recent studies have revealed a myriad of non-coding transcripts in different organisms. For instances, the presence of short bidirectional transcripts is a hallmark of active promoters in mammals, while upstream non-coding transcripts can be detected at most expressed genes in conditions where the R...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-44232 | biostudies-arrayexpress
GenomicsLong-range bidirectional transcription is a general feature of developmental gene promoters in mammals (ChIP-Seq 1)
Recent studies have revealed a myriad of non-coding transcripts in different organisms. For instances, the presence of short bidirectional transcripts is a hallmark of active promoters in mammals, while upstream non-coding transcripts can be detected at most expressed genes in conditions where the R...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-44577 | biostudies-arrayexpress
TranscriptomicsNPMâ??ALK permits the survival of thymic T cells with aberrant T cell receptor rearrangements enabling thymic escape and tumor development
We present evidence to support a new model of Anaplastic Large Cell Lymphoma (ALCL) pathogenesis in which the malignancy is initiated in early thymocytes, prior to TCR rearrangement which is bypassed in NPMâ??ALK transgenic mice following Notch1 expression. In support, we show that T cell receptor (...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-67131 | biostudies-arrayexpress
GenomicsLong-range bidirectional transcription is a general feature of developmental gene promoters in mammals (ChIP-Seq 2)
Recent studies have revealed a myriad of non-coding transcripts in different organisms. For instances, the presence of short bidirectional transcripts is a hallmark of active promoters in mammals, while upstream non-coding transcripts can be detected at most expressed genes in conditions where the R...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-45014 | biostudies-arrayexpress
UnknownA multinational cross-sectional study on the prevalence and predictors of long COVID across 33 countries.
Not available
S-EPMC12319108 | biostudies-literature
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