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TranscriptomicsHMGA1: A master regulator of tumor progression in triple-negative breast cancer cells
Emerging evidence suggests that tumor cells metastasize by co-opting stem cell transcriptional networks, although the molecular underpinnings of this process are poorly understood. Here, we show for the first time that the high mobility group A1 (HMGA1) gene drives metastatic progression in triple ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-45483 | biostudies-arrayexpress
TranscriptomicsThe Molecular Signature Induced by HMGA1 During Lymphoid Tumorigenesis
We are exploring the molecular pathways activated during lymphoid transformation with the long term goal of developing better therapies. Our focus is the HMGA1a oncogene because our studies indicate that it plays an important role in aggressive human lymphoid leukemia and lymphoma. We have developed...
ORGANISM(S): Mus musculus 
2013-01-30 | E-GEOD-22922 | biostudies-arrayexpress
TranscriptomicsGenomic signatures of a global fitness index in a multi-ethnic cohort of women
The rates of obesity and sedentary lifestyle are on a dramatic incline, with associated detrimental health effects among women in particular. Although exercise prescriptions are useful for overcoming these problems, success can be hampered by differential responsiveness among individuals in cardiova...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-34788 | biostudies-arrayexpress
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