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TranscriptomicsMultifaceted maturation of monocyte-derived dendritic cells stimulated by intracellular bacteria
Background: It has been shown that intracellular pathogens hijack DC functions to evade immune defense mechanisms. In this study, we investigated the responses of human monocyte derived DCs to four intracellular bacteria, Tropheryma whipplei, Coxiella burnetii, Brucella abortus and Orientia tsutsuga...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-49016 | biostudies-arrayexpress
TranscriptomicsInterferon-related transcriptional program is induced by chronic hepatitis E infection in kidney-transplant recipients
Background: Hepatitis E Virus (HEV) is a new causative agent of chronic hepatitis in solid organ transplant recipients in Europe. Factors associated with the occurrence and persistence of chronic HEV infection remain largely unknown but chronic evolution seems to be the consequence of hostM-bM-^@M-^...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-36539 | biostudies-arrayexpress
TranscriptomicsOrientia tsutsugamushi, the agent of scrub typhus, induces an inflammatory program in human macrophages
Scrub typhus is a life-threatening disease caused by Orientia tsutsugamushi, a bacterium that mainly infects endothelial cells in vitro and in vivo. Evidence suggests that the interaction of O. tsutsugamushi with myeloid cells may play a pivotal role in O. tsutsugamushi infection. We showed here tha...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-38194 | biostudies-arrayexpress
TranscriptomicsCoxiella burnetii, the agent of Q fever, persists in adipocytes
Coxiella burnetii, the agent of Q fever, persists in humans despite specific immune responses: however, its reservoir remains unknown. We detected C. burnetii in adipose tissue from BALB/c and C57/BL6 mice 4 months after infection when no bacteria were found in other tissues. C. burnetii infected cu...
ORGANISM(S): Mus musculus 
2014-05-25 | E-GEOD-46335 | biostudies-arrayexpress
TranscriptomicsSevere preeclampsia: new blood circulating biomarkers
Background: Preeclampsia (PE) is a placental disease characterized by hypertension and proteinuria in pregnant women, which is associated with a high maternal and infantile morbidity. However, circulating biomarkers able to predict the prognosis of PE are lacking. Methods: Thirty-eight women were in...
ORGANISM(S): Homo sapiens 
2014-05-14 | E-GEOD-48424 | biostudies-arrayexpress
TranscriptomicsRegulatory role of multinucleated giant cells derived from placental CD14+ macrophages: Pathophysiological implications
The role of placental macrophages is largely ignored in the success of pregnancy. We found that CD14+ macrophages purified from at-term placentas spontaneously matured into multinucleated giant cells (MGCs). MGCs lost the expression of CD14 and co-inhibitory molecules, such as Programmed cell Death-...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-38747 | biostudies-arrayexpress
TranscriptomicsThe multifaceted responses of human monocytes to IFN-gamma and IL-4 are not reducible to M1/M2 polarization of Macrophages
Macrophages are known to be polarized into inflammatory (M1) and immunoregulatory (M2) cells when they are stimulated by agonists such as IFN-gamma and IL-4, respectively. If circulating monocytes may be polarized in response to T cell signals is often misguidedly deduced from macrophage results. He...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-GEOD-36537 | biostudies-arrayexpress
TranscriptomicsGranulomatous response to Coxiella burnetii, the agent of Q fever: Activation of type I interferon-related genes
The formation of granulomas is associated with the resolution of Q fever, a zoonosis due to Coxiella burnetii; however the molecular mechanisms of granuloma formation remain poorly understood. We generated human granulomas with peripheral blood mononuclear cells and beads coated with C. burnetii, us...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-37666 | biostudies-arrayexpress
TranscriptomicsEvaluation of the effects of Lactobacillus sp. (ostrich) on body weight, the intestinal microbiome and metabolism in mice
Background. Food can affect the microbial balance in the human intestine, and the ingestion of probiotics may play a role in the current obesity pandemic. The objective of our study was to determine if increased Lactobacillus spp. in the intestinal microflora of mice can promote growth and if change...
ORGANISM(S): Mus musculus 
2010-09-21 | E-GEOD-24219 | biostudies-arrayexpress
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