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ProteomicsMicro-metastases regression following primary tumor excision: a critical role for primary tumor secretome
Numerous case studies have reported spontaneous regression of metastases following tumor excision, but underlying mechanisms are elusive. Here we present a model of metastases regression and latency elicited by the removal of a primary tumor, and identify underlying mechanisms. Human breast cancer c...
ORGANISM(S): Homo sapiens (Human) 
2020-10-07 | PXD008384 | Pride
Human Breast cancer Lc-ms Cancer microenvironment Secretome Metastasis 
ProteomicsExercise forms a metabolic-shield in distant organs blocking cancer progression and metastatic dissemination-Part 2
Exercise prevents cancer incidence and recurrence, yet the underlying mechanism remains mostly unknown. Here we report that exercise induces a metabolic reprogramming of internal organs, increasing their nutrient demand, thus protecting them against metastatic colonization by limiting nutrient avail...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035648 | Pride
Metabolism Cancer Exercise 
ProteomicsExercise forms a metabolic-shield in distant organs blocking cancer progression and metastatic dissemination-Part 1
Exercise prevents cancer incidence and recurrence, yet the underlying mechanism remains mostly unknown. Here we report that exercise induces a metabolic reprogramming of internal organs, increasing their nutrient demand, thus protecting them against metastatic colonization by limiting nutrient avail...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035630 | Pride
Metabolism Cancer Exercise 
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