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ProteomicsA comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans
DNA damage causes genomic instability underlying many diseases, with traditional analytical approaches providing minimal insight into the spectrum of DNA lesions in vivo. Here we used untargeted chromatography-coupled tandem mass spectrometry-based adductomics (LC-MS/MS) to define the landscape of D...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2023-09-12 | PXD045311 | Pride
Adductomics Strp mrm 
MetabolomicsMetabolome patterns identify active dechlorination in bioaugmentation consortium SDC-9

Ultra-high performance liquid chromatography-high resolution mass spectrometry (UPHLC-HRMS) is used to discover and monitor single or sets of biomarkers informing about metabolic processes of interest. The technique can detect thousands of molecules (i.e., metabolites) in a single instrument run ...

2022-09-16 | MTBLS5219 | MetaboLights
GenomicsWTCCC2 Pharmacogenomic Response to Statins study
A WTCCC2 project genome-wide study for pharmacogenomic response to statins (PR) in individuals from Scotland.
EGAS00000000121 | EGA
Genomicsena-DATASET-OCDEM-04-09-2015-16:46:25:090-47 - samples
The intersection of genome-wide association analyses with physiological and functional data indicates that variants regulating islet gene transcription influence type 2 diabetes (T2D) predisposition and glucose homeostasis. However, the specific genes through which these regulatory variants act rema...
EGAD00001001601 | EGA
Genomicscis-eQTL mapping of human pancreatic islets
The intersection of genome-wide association analyses with physiological and functional data indicates that variants regulating islet gene transcription influence type 2 diabetes predisposition and glucose homeostasis. However, the specific genes through which these regulatory variants act remain po...
EGAS00001001265 | EGA
GenomicsOxford Human Islet Data Access Committee
Data Access Committee EGAC00001000335
EGAC00001000335 | EGA
ProteomicsAnalysis of pre-and postsynaptic brain receptors, transporters and channels by mass spectrometry
Although receptors, transporters and channels (RTCs) are key elements in the synaptic membrane, work on analysis and quantification of RTCs by mass spectrometry is limited. Additionally, there is not a single mass spectrometrical study that assigns the localisation of RTCs to the pre- or post-synap...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-12-12 | PXD001948 | Pride
Transporters and channels Presynaptic Receptors Postsynaptic Membrane 
TranscriptomicsEffect of H19 Knockdown by siRNA on gene expression in C2C12 cells
We used microarrays to characterize the global changes in gene expression in C2C12 cells due to siRNA knockdown of long non-coding RNA H19 Control siRNA or siRNA specific for mouse H19 were transfected into day1 differentiating C2C12 myoblasts in triplicates. 40 H later total RNAs were isolated and ...
ORGANISM(S): Mus musculus 
2013-09-30 | E-GEOD-49535 | biostudies-arrayexpress
GenomicsNHLBI Family Heart Study (FamHS-Visit1 and FamHS-Visit2)

The Family Heart Study (FamHS) was funded by the National Heart, Lung, and Blood Institute (NHLBI). It was begun in 1992 with the ascertainment of 1,200 families, half randomly sampled, and half selected because of an excess of coronary heart disease (CHD) or risk factor abnormalities as compared...

phs000221.v1.p1 | EGA
GenomicsPR
Pharmacogenomic response to Statins samples (Genotypes/Phenotypes)
EGAD00010000282 | EGA
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