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ProteomicsImpaired presynaptic proteostasis in the initial stages of amyloid beta proteotoxicity
Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimers disease (AD); however, little is known about the early mechanisms that contribute to this accumulation. To objectively assess the impaired protein turnover at early stages of amyloid beta (Abeta) proteotoxic...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-24 | MSV000085004 | MassIVE
GenomicsPresynaptic dysfunction in CASK-related neurodevelopmental disorders
Presynaptic dysfunction in CASK-related neurodevelopmental disorders
PRJNA590196 | ENA
ProteomicsThe temporal profile of activity-dependent presynaptic phospho-signalling reveals long lasting patterns of post-stimulus regulation
Depolarization of presynaptic terminals stimulates calcium influx, which evokes neurotransmitter release and activates phosphorylation-based signalling. Here, we present the first global temporal profile of presynaptic activity-dependent phospho-signalling, which includes two KCl stimulation levels ...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-01-28 | PXD010007 | Pride
Neuron Phosphorylation Rat Phosphatase Signalling Synaptosome Presynaptic Depolarization Kinase Post-stimulus Pp1 
UnknownMolecular Characterization of an SV Capture Site in the Mid-Region of the Presynaptic CaV2.1 Calcium Channel C-Terminal.
Not available
S-EPMC5958201 | biostudies-literature
ProteomicsActive zone plasticity drives presynaptic dephosphorylation in Drosophila
The function of the nervous system relies on tightly regulated, yet plastic synaptic vesicle release machinery at the presynaptic active zone. In Drosophila, a form of presynaptic active zone plasticity, Presynaptic Scaling, or PreScale, is executed by the ELKS-family scaffold protein Bruchpilot (BR...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-06-09 | PXD067034 | Pride
Bruchpilot (brp) Phospho-proteomics Drosophila Presynaptic scaling Prescale Proteomics 
ProteomicsCB1 receptor-mediated inhibitory LTD triggers presynaptic remodeling via protein synthesis and ubiquitination
Long-lasting forms of postsynaptic plasticity commonly involve protein synthesis-dependent structural changes of dendritic spines. However, the relationship between protein synthesis and presynaptic structural plasticity remains unclear. Here, we investigated structural changes in cannabinoid-recept...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-23 | PXD020008 | Pride
Win 55 Neurons Cannabinoids Cb1 212-2 
ProteomicsMudPIT analyses of proteins associated with Piccolo and Bassoon in the presynaptic active zone
We used a 3-step protocol that separates lipid-associated proteins based on their buoyant density, size and charge. All steps were conducted either on ice or at 4C. Step 1 involved a sucrose density gradient centrifugation in which ca. 100 postnatal day 4 rat brains were homogenized in buffer A (5...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2016-07-11 | MSV000079897 | MassIVE
GenomicsCPEB2-activated axonal translation of VGLUT2 mRNA promotes glutamatergic transmission and presynaptic plasticity
CPEB2-activated axonal translation of VGLUT2 mRNA promotes glutamatergic transmission and presynaptic plasticity
PRJNA860927 | ENA
GenomicsCombinatorial codes of presynaptic organizer neurexins orchestrate precise olfactory axon targeting
Combinatorial codes of presynaptic organizer neurexins orchestrate precise olfactory axon targeting
PRJNA1046110 | ENA
GenomicsPlekhg5 regulates the unconventional secretion of Sod1 by presynaptic secretory autophagy
Plekhg5 regulates the unconventional secretion of Sod1 by presynaptic secretory autophagy
PRJNA1122581 | ENA
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