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ProteomicsThe temporal profile of activity-dependent presynaptic phospho-signalling reveals long lasting patterns of post-stimulus regulation
Depolarization of presynaptic terminals stimulates calcium influx, which evokes neurotransmitter release and activates phosphorylation-based signalling. Here, we present the first global temporal profile of presynaptic activity-dependent phospho-signalling, which includes two KCl stimulation levels ...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-01-28 | PXD010007 | Pride
Neuron Phosphorylation Rat Phosphatase Signalling Synaptosome Presynaptic Depolarization Kinase Post-stimulus Pp1 
UnknownHuman visual processing during walking: Dissociable pre- and post-stimulus influences.
Not available
S-EPMC9771827 | biostudies-literature
UnknownDisplacement detection is suppressed by the post-saccadic stimulus.
Not available
S-EPMC7283269 | biostudies-literature
TranscriptomicsExpression data from advanced Parkinson's disease (PD) patients leukocytes - prior to and following deep brain stimulation (DBS) treatment in on and off stimulation conditions, and matched healthy control (HC) subjects
Sub-thalamic deep brain stimulation (DBS) reversibly modulates ParkinsonM-bM-^@M-^Ys disease (PD) motor symptoms, providing an unusual opportunity to compare leukocyte transcripts in the same subjects before and after neurosurgery and after disconnecting the stimulus (ON-and OFF-stimulus). Here, we ...
ORGANISM(S): Homo sapiens 
2012-01-09 | E-GEOD-23676 | biostudies-arrayexpress
TranscriptomicsReversal of persistent wound-induced retinal pigmented epithelial-to-mesenchymal transition by the TGFb pathway inhibitor, A-83-01.
Age-related macular degeneration (AMD) is a leading cause of blindness. Most vision loss occurs following the transition from a disease of deposit formation and inflammation to a disease of neovascular fibrosis and/or cell death. Here, we investigate how repeated wound stimulus leads to seminal chan...
ORGANISM(S): Homo sapiens 
2015-07-06 | E-GEOD-67898 | biostudies-arrayexpress
TranscriptomicsEarly Response Genes in Osteoblasts Exposed to Dynamic Fluid Flow
Cyclic mechanical loads applied to the skeleton increase bone formation. Dynamic fluid flow is a potent anabolic stimulus for cultured osteoblasts. In this study, gene profiles involved in mediating the anabolic response of MC3T3 osteoblasts to dynamic fluid flow are investigated. MC3T3 osteoblast R...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-16211 | biostudies-arrayexpress
UnknownPost-stimulus beta responses are modulated by task duration.
Not available
S-EPMC6985901 | biostudies-literature
TranscriptomicsGene expression changes in the periventricular white matter of neonatal piglets at a defined 48h time point following a hypoxic-ischemic insult: a comparison of piglets left untreated and those treated with a remote post-conditioning stimulus applied to the hind leg immediately after the insult.
Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention whereby brief episodes of ischemia/reperfusion of one organ (limb) mitigate damage in another organ (brain) that has experienced severe hypoxia-ischemia. 16 Large White newborn female piglets were exposed to a tightl...
ORGANISM(S): Sus scrofa 
2016-09-21 | E-MTAB-5125 | biostudies-arrayexpress
ProteomicsThe temporal profile of activity-dependent presynaptic phospho-signalling reveals a PP1-dependent reduction in vesicle release
Depolarization of presynaptic terminals stimulates calcium influx, which evokes neurotransmitter release and activates phosphorylation-based signalling. Here, we present the first global temporal profile of presynaptic proteins undergoing post-stimulus phospho-signalling to reveal long-lasting chang...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-01-24 | PXD008495 | Pride
Synaptosome Lc-ms Phosphatase Phosphorylation 
UnknownLayer 4 pyramidal neuron dendritic bursting underlies a post-stimulus visual cortical alpha rhythm.
Not available
S-EPMC7214406 | biostudies-literature
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