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After depolarization treatment, a series of membrane protein were changed significantly. We collected the total membrane protein of the mouse peritoneal macrophages as previously (Karmakar et al., 2020), and then analyzed by Mass Spectrometry
ORGANISM(S): Mus musculus (Mouse) 
2022-05-07 | PXD033322 | Pride
RNAseq after cortical spreading depolarization (SD)
The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway
we used DNA microarray analysis to identify genes that are induced by neuronal activity in excitatory neurons at the time when inhibitory synapses are forming and maturing on them. Keywords: Primary neuron culture, depolarization, activity-dependent
ORGANISM(S): Mus musculus 
2008-09-24 | GSE11256 | GEO
Genomic decoding of neuronal depolarization by stimulus-specific NPAS4 heterodimers, RNA sequencing
PURPOSE: To assess the role of Apollon in melanoma resistance to intrinsic and extrinsic pathways of apoptosis and to identify strategies to reduce its expression. EXPERIMENTAL DESIGN: Expression of Apollon was assessed in melanoma cell lines and in surgical specimens.Gene expression profiling, m...
ORGANISM(S): Homo sapiens 
Oncogenic signals can induce premature senescence (OIS) in normal human cells causing a proliferation arrest and the elimination of these defective cells by immune cells. In order to identify new regulators of OIS, we performed a loss-of-function genetic screen and identified that the loss of SCN9A ...
ORGANISM(S): Homo sapiens 
2018-02-21 | GSE110884 | GEO
Cells regulate gene expression in response to salient external stimuli. In neurons, depolarization leads to the expression of inducible transcription factors (ITFs) that direct subsequent gene regulation. Depolarization encodes both a neuron’s action potential (AP) output and synaptic inputs, via ex...
ORGANISM(S): Rattus norvegicus 
2019-10-02 | GSE134203 | GEO
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