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ProteomicsAurora B opposes PP1 function in mitosis through phosphorylation of the conserved RVxF binding motif in PP1 regulatory proteins
Protein phosphatase 1 (PP1) is a highly conserved protein phosphatase that opposes the actions of a diverse set of Ser-Thr protein kinases by controlling the majority of serine-threonine (Ser-Thr) dephosphorylation reactions in eukaryotes. PP1 gains substrate specificity through binding to a large n...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-03-30 | MSV000082226 | MassIVE
GenomicsCaldicellulosiruptoraceae bacterium PP1
Caldicellulosiruptoraceae bacterium PP1 Genome sequencing
PRJNA1146399 | ENA
ProteomicsPPP1R2 (Inhibitor 2) stimulates protein phosphatase PP1 through stabilisation of dynamic subunit interactions
Protein Ser/Thr phosphatase PP1 is always associated with one or two regulatory subunits or RIPPOs. One of the earliest evolved RIPPOs is PPP1R2, also known as Inhibitor-2. Since its discovery nearly 5 decades ago, PPP1R2 has been variously described as an inhibitor, activator or (metal) chaperone o...
ORGANISM(S): Homo sapiens (Human) 
2024-11-13 | PXD052317 | Pride
Pp1 Holoenzyme Ppp1r2 
TranscriptomicsExpression profiling of HeLa Tet-off cells expressing Flag-tagged version of WT NIPP1 or PP1 binding mutant of NIPP1.
NIPP1, an established interactor of protein phosphatase 1 (PP1), is implicated in PRC2-mediated regulation of gene expression. Here, we explore whether PP1 associated with NIPP1 is involved in NIPP1-mediated regulation of genes. Therefore, we generated Hela Tet-off (HTO) cell lines that stably and i...
ORGANISM(S): Homo sapiens 
2010-07-19 | E-GEOD-19642 | biostudies-arrayexpress
ProteomicsIdentification of PP1-fusion phosphatase substrates
This experiments was designed to identify substrates of holophosphatase complexes of PP1 and its specificity-determining regulator proteins. We generated fusions of Flag-tagged Protein Phosphatase 1 fusions with Phactr1-4, Neurabin, Spinophilin, PPPR15A, PPP1R15B, and PNUTS, in each case including k...
ORGANISM(S): Homo sapiens (Human) 
2025-05-28 | PXD055166 | Pride
Spinophilin Tmt Phosphatase Phosphoproteomics Phactr1 Pp1 
TranscriptomicsMapping and characterization of promoter-binding sites of protein phosphatase 1
Protein phosphatase 1 (PP1) is a Ser/Thr phosphatase that has been implicated in many key cellular functions including transcriptional regulation. Due to its involvement these many processes, it becomes difficult to directly link PP1 to transcriptional regulation on the chromatin level as no direct ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-54170 | biostudies-arrayexpress
GenomicsPseudomonas syringae pv. pisi str. PP1
Pseudomonas syringae pv. pisi str. PP1 Genome sequencing
PRJNA211606 | ENA
TranscriptomicsTranscriptional profiling of Neurospora crassa cells containing MAK2Q100G allele: Exposure to ATP-analog (1NM-PP1) vs control
To study the consequences of MAK-2 activity modulation during vegetative cell fusion, we took advantage of a previously constructed allele of MAK-2 (MAK-2Q100G) to specifically perturb kinase signaling during germling vegetative cell fusion (inhibition of MAK-2Q100G activity by addition of the ATP a...
ORGANISM(S): Neurospora crassa OR74A 
2013-06-01 | E-GEOD-46912 | biostudies-arrayexpress
GenomicsBacillus altitudinis strain:PP1
Bacillus altitudinis strain:PP1 Genome sequencing
PRJNA1510170 | ENA
TranscriptomicsProtein phosphatase PP1-NIPP1 activates mesenchymal genes in HeLa cells
The deletion of the protein phosphatase-1 (PP1) regulator NIPP1 is embryonic lethal during gastrulation, hinting at a key role of PP1-NIPP1 in lineage specification. Consistent with this notion we show here that a mild, stable overexpression of NIPP1 in HeLa cells caused a massive in...
ORGANISM(S): Homo sapiens 
2015-04-04 | E-GEOD-67558 | biostudies-arrayexpress
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