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ProteomicsProximity labeling and orthogonal nanobody pulldown (ID-oPD) approaches to map the spinophilin interactome uncover a role for spinophilin in protein regulation.
The major synaptic protein phosphatase 1 (PP1) targeting protein, spinophilin can inhibit or target PP1 activity towards diverse substrates. To detail the full panoply of substrates at which spinophilin modulates PP1 activity, we have validated a novel approach that permits proximity labeling and or...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-12-02 | MSV000096575 | MassIVE
ProteomicsConsequences of loss of spinophilin on striatal mGluR5 phosphorylation and interactome
Constitutive knockout of the obsessive-compulsive disorder-associated protein, SAPAP3, results in repetitive motor dysfunction, such as excessive grooming, caused by increased mGluR5 activity in striatal medium spiny neurons (MSNs). However, signaling mechanisms that mediate mGluR5-dependent groomin...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-14 | PXD034053 | Pride
Phosphatase targeting proteins Striatum Mouse Tmt-lc/ms 
TranscriptomicsSpinophilin silencing in the breast cancer cell line SUM159
Microarray profiling was used to determine the most abundantly expressed genes in spinophilin-silenced breast cancer cells compared to control cells in the cell line SUM159. We identified several differentially expressed genes in spinophilin-silenced cells.
ORGANISM(S): Homo sapiens 
2014-10-01 | GSE61889 | GEO
TranscriptomicsSpinophilin silencing in the breast cancer cell line SUM159
Microarray profiling was used to determine the most abundantly expressed genes in spinophilin-silenced breast cancer cells compared to control cells in the cell line SUM159. We identified several differentially expressed genes in spinophilin-silenced cells. A total number of six samples were analyze...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-61889 | biostudies-arrayexpress
GenomicsHomo sapiens
Spinophilin silencing in the breast cancer cell line SUM159
PRJNA262625 | ENA
UnknownProximity labeling and orthogonal nanobody pulldown (ID-oPD) approaches to map the spinophilin interactome uncover a putative role for spinophilin in protein homeostasis.
Not available
S-EPMC11785182 | biostudies-literature
UnknownFlexibility in the PP1:spinophilin holoenzyme.
Not available
S-EPMC3017638 | biostudies-literature
UnknownMechanisms of spinophilin-dependent pancreas dysregulation underlying diabesity.
Not available
S-EPMC9934546 | biostudies-literature
UnknownSpinophilin participates in information transfer at immunological synapses.
Not available
S-EPMC2315669 | biostudies-literature
UnknownLow spinophilin expression enhances aggressive biological behavior of breast cancer.
Not available
S-EPMC4484449 | biostudies-literature
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