Holoenzyme - OmicsDI

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Unknown (1187)
Transcriptomics (188)
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Proteomics (64)
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Methylation profiling (1)

Organisms

Homo sapiens (74)
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Danio rerio (9)
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Synechocystis sp. PCC 6803 (5)
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Mesorhizobium metallidurans STM 2683 (1)
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Papilio xuthus (1)
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Dictyostelium discoideum (1)
Spodoptera frugiperda (1)
Methanococcoides burtonii (1)
Brassica rapa (1)
Streptomyces coelicolor A3(2) (1)
Apis mellifera (1)
Vitis vinifera (1)

Organisms

Mus musculus (14)
Homo sapiens (11)
Escherichia coli str. K-12 substr. MG1655 (5)
Synechocystis sp. PCC 6803 (3)
Schizosaccharomyces pombe (2)
Escherichia coli (2)
Synechocystis sp. PCC 6803 substr. GT-T (1)
Francisella tularensis (1)
Mycolicibacterium smegmatis (1)
Caenorhabditis elegans (1)
Candida albicans (1)
Escherichia coli K-12 (1)
Bacillus subtilis subsp. subtilis str. 168 (1)
Mycobacterium tuberculosis (1)
Arabidopsis thaliana (1)
Oryza sativa Japonica Group (1)

Repository

biostudies-arrayexpress (163)
ENA (60)
geo (49)
pride (35)
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iProX (9)
EGA (8)
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jPOST (2)
GPMDB (1)
PanoramaPublic (1)

Tissue

Cell culture (9)
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Leaf (2)
Fibroblast (2)
Lung (2)
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Head (1)
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Seed (1)
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Heart (1)
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Hepatocyte (1)
Epithelial cell (1)
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T cell (1)

Disease

Not Available (1)
Heart conduction disease (1)
Lung small cell carcinoma (1)
Liver cancer (1)
Breast cancer (1)
Disease free (1)

Technology Type

Mass Spectrometry (35)
Shotgun proteomics (16)
Affinity purification coupled with mass spectrometry proteomics (9)
Bottom-up proteomics (7)
Mass spectrometry assay (4)
Mass spectrometry (4)
Data-dependent acquisition (4)
Chemical cross-linking coupled with mass spectrometry proteomics (3)
Data-independent acquisition (2)
SRM/MRM (2)
Gel-based experiment (2)
Illumina HiSeq 2500 (1)
HDMSE (1)

Instrument Platform

Illumina HiSeq 2000 (25)
Illumina HiSeq 2500 (20)
Illumina HiSeq 4000 (18)
Q Exactive Plus (12)
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Orbitrap Fusion (5)
Liquid Chromatography MS - positive - reverse phase (5)
Illumina NovaSeq 6000 (4)
Liquid Chromatography MS - negative - reverse phase (4)
MacBook Pro 64Gb RAM; 16-core (1)
Qubit 2.0 Fluorometer; Agilent TapeStation 4200 (1)
HiSeq2000/4000 (1)
Hiseq2000/4000 (1)
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Not applicable (1)
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NextSeq 500 (1)
Instrument (1)
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LTQ (1)
Liquid Chromatography MS - (1)
Liquid Chromatography MS - negative - HILIC (1)
Liquid Chromatography MS - positive - HILIC (1)
Liquid Chromatography MS - negative - hilic (1)
Liquid Chromatography MS - positive - hilic (1)

Publication Date

2021 (29)
2015 (24)
2025 (21)
2014 (20)
2016 (19)
2026 (18)
2024 (18)
2023 (16)
2013 (16)
2020 (14)
2022 (13)
2019 (11)
2017 (11)
2018 (9)
2012 (9)
2011 (7)
2010 (7)
2007 (7)
2008 (4)
2009 (1)
2006 (1)

CHEBI ID

CHEBI:18237 (2)
CHEBI:83050 (1)
CHEBI:81132 (1)
CHEBI:87289 (1)
CHEBI:169039 (1)
CHEBI:71418 (1)
CHEBI:178475 (1)
CHEBI:183816 (1)
CHEBI:166705 (1)
CHEBI:180283 (1)
CHEBI:135791 (1)
CHEBI:86545 (1)
CHEBI:35045 (1)
CHEBI:68428 (1)
CHEBI:25801 (1)
CHEBI:46968 (1)
CHEBI:18083 (1)
CHEBI:6857 (1)
CHEBI:41633 (1)
CHEBI:140570 (1)
CHEBI:87287 (1)
CHEBI:171994 (1)
CHEBI:65210 (1)
CHEBI:146130 (1)
CHEBI:50591 (1)
CHEBI:1606 (1)
CHEBI:27584 (1)
CHEBI:28617 (1)
CHEBI:67252 (1)
CHEBI:28937 (1)

Metabolite Name

Deisopropylatrazine (3)
Neosaxitoxin (3)
L-Cystathionine (3)
Picolinic acid (3)
Methylimidazoleacetic acid (3)
Corticosterone (3)
Betaine (3)
Paraxanthine (3)
Acetylcysteine (3)
Erucic acid (3)
Tetrahydrocortisone (3)
Pyridoxine (3)
1-Methylhistidine (3)
Pyridoxamine (3)
Theobromine (3)
Cholesterol (3)
Pantothenic acid (3)
L-Kynurenine (3)
L-Histidine (3)
Cortisol (3)
Indole (3)
Choline (3)
Sebacic acid (3)
Tyramine (3)
Pipecolic acid (3)
Spermidine (3)
Guanine (3)
2-Hydroxycinnamic acid (3)
Riboflavin (3)
Cytidine (3)

First Public Date

2023 (11)
2026 (8)
2014 (8)
2025 (7)
2024 (6)
2022 (4)
2020 (4)
2021 (3)
2017 (3)
2018 (2)
2019 (1)
2016 (1)
2015 (1)
2013 (1)

Classification

bacteria (10)
fungi (1)

Study type

RNA-seq of coding RNA (94)
Transcription profiling by array (38)
ChIP-seq (11)
ChIP-chip by tiling array (3)
High-throughput sequencing (3)
Methylation profiling by high throughput sequencing (2)
RNA-seq of total RNA (2)
RNA-seq of non coding RNA (2)
Plant - High-throughput sequencing (1)
Animal - High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
Transcription profiling by tiling array (1)
RNAi profiling by array (1)
Comparative genomic hybridization by array (1)
Other (1)
MicroRNA profiling by array (1)

Release Date

2015 (90)
2021 (85)
2025 (78)
2014 (78)
2016 (77)
2022 (72)
2020 (71)
2019 (71)
2023 (69)
2017 (69)
2013 (63)
2024 (61)
2018 (60)
2012 (55)
2011 (54)
2010 (54)
2008 (41)
2007 (41)
2009 (40)
2006 (30)
2003 (15)
2000 (13)
2004 (12)
2026 (10)
2005 (10)
2001 (10)
1998 (9)
1999 (5)
2002 (3)
1997 (3)

Lab affiliation

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China (2)
Department of Cellular and Molecular Medicine, KU Leuven, Belgium (1)
Ikerbasque Researcher, Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, UPV/EHU, Leioa 48940, Bizkaia, Spain (1)
Biomolecular Mass Spectrometry and Proteomics Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands, Janssen Infectious Diseases and Vaccines, Crucell Holland B.V., Leiden, the Netherlands (1)
Director of Research Head, Signalling and Transcription Group The Francis Crick Institute 1 Midland Road, London NW11AT, UK (1)
Sainsbury Laboratory Norwich (1)
Proteome Dynamics, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Rössle-Str. 10, 13125 Berlin, Germany Charité -Universitätsmedizin Berlin, 10117 Berlin, Germany (1)
Director of Research Head, Signalling and Transcription Group The Francis Crick Institute, 1 Midland Road, London, UK (1)
Department of Chemistry, Pennsylvania State University (1)
Univ. Grenoble Alpes, INSERM, CEA, UMR BioSanté U1292, CNRS, CEA, FR2048, 38000 Grenoble, France (1)
Laboratory of Biosignaling & Therapeutics, KU Leuven Department of Cellular and Molecular Medicine, University of Leuven, B-3000 Leuven, Belgium. (1)
Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary Department of Chemistry, University of Calgary (1)
Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, US (1)
Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US41 – UAR 2014 – PLBS, F-59000 Lille, France (1)
Laboratory of Molecular Microbiology, School of Biological Sciences, and Institute of Microbiology, Seoul National University, Seoul 08826, Korea (1)
Professor of Pediatrics and Genetics co-Director of the Cancer Biology PhD program Harriet and Mary Zelencik Scientist in Children's Cancer and Blood Diseases 265 Campus Drive, SIM1 Bldg - Rm G2078a - Stanford, CA 94305-5457, USA (1)
Faculty of Biology, Technion - Israel Institute of Technology, Haifa 32000, Haifa, Israel (1)
University of New Hampshire (1)
Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164, United States (1)
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (1)
UC San Francisco (1)
Dept. Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Sweden (1)
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA (1)
Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. (1)
Department of Biochemistry, University of Missouri, USA (1)
MRC PPU, School of Life Sciences University of Dundee (1)
Faculty of Biology, Medicine and Health, The University of Manchester (1)
EMBL, Heidelberg (1)
University of Iowa (1)
Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China (1)

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Multiplicity of regulatory subunit conformations define structural ensemble of reset Protein Kinase A holoenzyme

How Protein kinase A (PKA) is reset to a basal state following 3’5’cyclic adenosine monophosphate(cAMP)-mediated activation is unknown. Here we describe the mechanism of cAMP-PKA signal termination leading to reset of PKA by holoenzyme formation through the obligatory action of phosphodiesterases (P...

ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human)

2025-07-14 | PXD061315 | Pride

The protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii

Phenotypic switching from tachyzoite to bradyzoite and vice versa is the fundamental mechanism underpinning the pathogenicity and adaptability of the protozoan parasite Toxoplasma gondii. Accumulation of cytoplasmic starch granules is a hallmark of the quiescent bradyzoite stage. The regulatory fact...

ORGANISM(S): Toxoplasma gondii

2022-11-05 | PXD033120 | Pride

Pp2a holoenzyme Toxoplasma gondii Differentiation Dephosphorylation. Starch metabolism

CaMKII activation and dynamics are independent of the holoenzyme structure: an infinite subunit holoenzyme approximation.

Not available

S-EPMC3507550 | biostudies-literature

The PP2A-2 holoenzyme orchestrates daughter cell emergence during cytokinesis in Toxoplasma gondii

Toxoplasma gondii is a significant pathogen affecting both humans and animals, with clinical symptoms primarily driven by the uncontrolled proliferation of tachyzoites. In this study, we reveal the essential role and functional plasticity of the PP2A-2 holoenzyme in orchestrating daughter cell emerg...

ORGANISM(S): Toxoplasma gondii

2025-08-21 | PXD064226 | Pride

Toxoplasma gondii pp2a-2 phosphatase cytokinesis cell division daughter cell emergence phosphoproteomics

Yeast PKA holoenzyme and condensate targeted and label-free proteomics

Protein kinase A (PKA) is a conserved kinase essential for many biological processes linked to growth, development and metabolism. The PKA catalytic subunit is expressed as multiple isoforms in diverse eukaryotes; however, their contribution to ensuring specificity in response to environmental cues ...

ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast)

2025-09-19 | PXD045310 | Pride

Holoenzyme Yeast Condensates Heat stress Pka isoforms

The architecture of Tetrahymena telomerase holoenzyme.

Not available

S-EPMC3817743 | biostudies-literature

Flexibility in the PP1:spinophilin holoenzyme.

Not available

S-EPMC3017638 | biostudies-literature

Characterization of CaMKIIα holoenzyme stability.

Not available

S-EPMC7255518 | biostudies-literature

Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme.

Not available

S-EPMC4497662 | biostudies-literature

How a holoenzyme for DNA replication is formed.

Not available

S-EPMC3538194 | biostudies-literature

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