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ProteomicsMultiplicity of regulatory subunit conformations define structural ensemble of reset Protein Kinase A holoenzyme
How Protein kinase A (PKA) is reset to a basal state following 3’5’cyclic adenosine monophosphate(cAMP)-mediated activation is unknown. Here we describe the mechanism of cAMP-PKA signal termination leading to reset of PKA by holoenzyme formation through the obligatory action of phosphodiesterases (P...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-07-14 | PXD061315 | Pride
Reset Conformational dynamics Signal termination Phosphodiesterase Protein kinase a 
TranscriptomicsRNA-seq of chemically reset human naive pluripotent stem cells
A simple method is presented to reset human pluripotent cells to a naive state via transient histone deacetylase inhibition and maintenance in chemically-defined naive stem cell culture media. Cells can be reset without transgenes and expanded continuously either on feeders or alternative substrates...
ORGANISM(S): Homo sapiens 
2017-08-07 | E-MTAB-5674 | biostudies-arrayexpress
TranscriptomicsMicroarray expression profiling of conventional and reset human pluripotent stem cells
Human pluripotent cells were reset to ground state pluripotency by transient overexpression of NANOG and KLF2 and subsequent inhibition of ERK and protein kinase C. Transcriptional profiling of H9 parental and clonal lines, and induced pluripotent stem cells derived from adult fibroblast and adipose...
ORGANISM(S): Homo sapiens 
2014-09-10 | E-MTAB-2856 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of conventional and reset human pluripotent stem cells
Human pluripotent cells were reset to ground state pluripotency by transient overexpression of NANOG and KLF2 and subsequent inhibition of ERK and protein kinase C. Transcriptional profiling of reset cells and conventional pluripotent stem cell cultures was carried out by RNA-seq, in tandem with mou...
ORGANISM(S): Mus musculus 
2014-09-10 | E-MTAB-2857 | biostudies-arrayexpress
GenomicsRNA-seq of chemically reset human naive pluripotent stem cells
RNA-seq of chemically reset human naive pluripotent stem cells
PRJEB20388 | ENA
GenomicsRNA sequencing of conventional and reset human pluripotent stem cells
RNA sequencing of conventional and reset human pluripotent stem cells
PRJEB7132 | ENA
UnknownThe death of a neurotrauma trial lessons learned from the prematurely halted randomized evaluation of surgery in elderly with traumatic acute subdural hematoma (RESET-ASDH) trial.
Not available
S-EPMC11342112 | biostudies-literature
TranscriptomicsReproduction of reset cell
Functional-assay limitations are an emerging issue in characterizing human pluripotent stem cells (hPSCs). With rodent PSCs, chimera formation, using pre-implantation embryos, is the gold-standard assay of pluripotency. In hPSCs, this can only be monitored via teratoma formation or in vitro differ...
ORGANISM(S): Homo sapiens 
2015-03-10 | E-GEOD-66657 | biostudies-arrayexpress
UnknownStatistical characteristics of reset switching in Cu/HfO2/Pt resistive switching memory.
Not available
S-EPMC4493841 | biostudies-literature
UnknownReset of human neocortical oscillations during a working memory task.
Not available
S-EPMC164690 | biostudies-literature
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