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TranscriptomicsRNA polymerase II termination involves CTD tyrosine dephosphorylation by CPF subunit Glc7
At the 3'-ends of genes, RNA polymerase (Pol) II is dephosphorylated at tyrosine 1 residues of its C-terminal domain (CTD), resulting in recruitment of transcription termination factors. We show that the multisubunit cleavage and polyadenylation factor (CPF) is a Pol II CTD phosphatase and its Glc7 ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-16 | E-MTAB-1528 | biostudies-arrayexpress
ProteomicsTargeted dephosphorylation of TFEB promotes its nuclear translocation
Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localised to the cytoplasm. Stressor-mediated reduction of TFEB phosphorylation prom...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD053311 | Pride
Adphosphotase Dephosphorylation Bdpic Ppp2ca Tfeb Phostac 
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019788 | Pride
Dephosphorylation Phospho-proteomics Mitotic exit Cell cycle Mitosis 
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019787 | Pride
Dephosphorylation Mitotis Mitotic exit Cell cycle Apc/c 
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019786 | Pride
Dephosphorylation Mitosis Phospho-proteomics Mitotic exit Cell cycle Pp1 Apcc 
ProteomicsDIA-MS Detect the Dephosphorylation of Tau by Phosphorylation Targeting Chimera (PhosTAC)
Microtubule-associated protein tau is essential for microtubule assembly and stabilization. Hyperphosphorylation of the microtubule-associated protein tau plays an important pathological role in the development of Alzheimer’s disease and other tauopathies, one of the greatest unmet demands in the cl...
ORGANISM(S): Homo sapiens (Human) 
2023-03-16 | PXD037459 | Pride
Dephosphorylation Dia-ms Tau Phostac Phosphoproteomics 
ProteomicsCasein phoshopeptides identification by partial-, double-dephosphorylation and endoGluC digestion
The aim of the present study was the development of a relatively simple method without enrichment step to detect, in a mixture of peptides and phosphopeptides, a maximum of CPPs, including multi-phosphorylated and large-size CPPs, by using high pressure liquid chromatography (HPLC), high-resolution ...
ORGANISM(S): Bos taurus (Bovine) 
2021-09-29 | PXD027132 | Pride
Dephosphorylation Mass spectrometry Casein phosphopeptides Endogluc digestion 
GenomicsPPP6R3-mediated dephosphorylation regulates mRNA translation during spermatogonial differentiation
PPP6R3-mediated dephosphorylation regulates mRNA translation during spermatogonial differentiation
PRJNA1165730 | ENA
ProteomicsAn affinity-directed phosphatase (AdPhosphatase) system for targeted protein dephosphorylation
Reversible protein phosphorylation, catalysed by protein kinases and phosphatases, is a fundamental process that controls protein function and intracellular signalling. Failure of phospho-control accounts for many human diseases. While a kinase phosphorylates multiple substrates, a substrate is o...
ORGANISM(S): Homo sapiens (Human) 
2023-02-01 | PXD039200 | Pride
Affinity-directed phosphatase  adphosphatase  targeted dephosphorylation  ppp1ca ppp2ca  nanobody  ulk1  fam83d 
ProteomicsTargeted dephosphorylation of TFEB promotes its nuclear translocation
Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localised to the cytoplasm. Stressor-mediated reduction of TFEB phosphorylation prom...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD053308 | Pride
Bdpic Ppp2ca Tfeb Adphosphatase Phostac 
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