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TranscriptomicsExpression data from WT and Aire KO thymic medullary epithelial cells (MECs)
The aim of this study is to analyze the transcriptional effects of Aire deficiency in the thymus, using the Affymetrix MoGene platform to analyze variation in exon usage MECs were isolated from 4-6 wk-old WT or Aire KO ((B6xNOD)F1 background) mice. Three WT and three Aire-KO mice taken individually ...
ORGANISM(S): Mus musculus 
2011-11-23 | E-GEOD-33878 | biostudies-arrayexpress
TranscriptomicsGene expression profile of conventional T cells (Tconv) and regulatory T cells (Treg) stimulated with anti-costimulatory molecule antibodies
Co-stimulatory molecules of the CD28 family on T lymphocytes integrate cues from innate immune system sensors, and modulate activation responses in conventional CD4+ T cells (Tconv) and their FoxP3+ regulatory counterparts (Treg). To better understand how costimulatory and co-inhibitory signals migh...
ORGANISM(S): Mus musculus 
2012-11-15 | E-GEOD-42276 | biostudies-arrayexpress
TranscriptomicsRapid, high efficiency isolation of pancreatic ß-cells
The ability to isolate pure pancreatic ß-cells would greatly aid multiple areas of diabetes research. We developed an exendin-4-like neopeptide conjugate for the rapid purification and isolation of functional pancreatic ß-cells. By targeting the glucagon-like peptide-1 receptor, ß-cells were isolate...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-64508 | biostudies-arrayexpress
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsNaturally transmitted segmented filamentous bacteria segregate with diabetes protection in NOD mice
Vertebrates typically harbor a rich gastrointestinal microbiota, which has co-evolved with the host over millennia and is essential for several of its physiological functions, in particular maturation of the immune system. Recent studies have highlighted the importance of a single bacterial species,...
ORGANISM(S): Mus musculus 
2011-06-09 | E-GEOD-29806 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse RTOC cell cultures
Four independent chip hybridization with RNAs from four independent RTOC cultures.
ORGANISM(S): Mus musculus 
2007-11-08 | E-GEOD-1112 | biostudies-arrayexpress
TranscriptomicsDeficiency of CXCR2, but Not Other Chemokine Receptors, Attenuates Autoantibody-Mediated Arthritis in a Murine Model
To examine patterns of gene expression in ankle synovial fluid cells and peripheral blood leukocytes during serum transferred arthritis. A time-course microarray analysis of serum-transferred arthritis was performed, examining ankle tissue, synovial fluid, and peripheral blood leukocytes.
ORGANISM(S): Mus musculus 
2011-02-24 | E-GEOD-27492 | biostudies-arrayexpress
TranscriptomicsRetinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4(+)CD44(hi) Cells.
CD4(+)Foxp3(+) regulatory T (Treg) cells originate primarily from thymic differentiation, but conversion of mature T lymphocytes to Foxp3 positivity can be elicited by several means, including in vitro activation in the presence of TGF-beta. Retinoic acid (RA) increases TGF-beta-induced expression o...
ORGANISM(S): Mus musculus 
2008-11-16 | E-GEOD-13306 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse OTI CD8 T cells transferred to irradiated syngeneic hosts
A time course of OTI CD8 T cells transferred to irradiated syngeneic hosts (or unirradiated hosts as control).
ORGANISM(S): Mus musculus 
2007-11-02 | E-GEOD-1921 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of CD4+CD25+ Tregs from NOD and B6.H2g7 mice
The NOD (nonobese diabetic) mouse strain develops a characteristic autoimmune syndrome that closely resembles human type I diabetes. It has been suggested that NOD mice exhibit both numerical deficiency in CD4+CD25+ regulatory T cells (Treg) and reduced suppressive activity. We compared sorted CD4...
ORGANISM(S): Mus musculus 
2008-12-19 | E-GEOD-6813 | biostudies-arrayexpress
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