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TranscriptomicsTranscription profiling of human skin biopsies from atopic eczema and healthy controls
The aim of this study was to find disease-associated genes in atopic eczema. Experiment Overall Design: Skin biopsies were analyzed from ten patients with active atopic eczema and ten healthy controls.
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6012 | biostudies-arrayexpress
TranscriptomicsAllergen challenged CD4+ cells from allergic patients and healthy controls
Gene expression (Npatients = 21, Ncontrols = 21) of CD4+ T-cells failed to seperate patients with seasonal allergic rhinitis (SAR) and healthy controls in an in vitro model system in which purified PBMCs from patients and healthy controls were challenged with allergen for 7 days. PBMCs from 21 patie...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-50223 | biostudies-arrayexpress
TranscriptomicsDNA Methylation Changes in Allergic Patients Correlate with Symptom Severity [methylation]
Altered DNA methylation patterns in CD4+ T-cells indicate the importance of epigenetic mechanisms in inflammatory diseases. However, the identification of these alterations is complicated by the heterogeneity of most inflammatory diseases. Seasonal allergic rhinitis (SAR) is an optimal disease model...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-50222 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in MZ twins discordant for IAR [in vivo]
Gene expression analysis in CD4+ T cells extracted from PBMCs, isolated from discordant MZ twins with IAR during season MZ twins discordant for intermittent allergic rhinitis (IAR)
ORGANISM(S): Homo sapiens 
2012-04-14 | E-GEOD-37155 | biostudies-arrayexpress
TranscriptomicsRapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems
Comparison of the methylation profile of mouse embryonic fibroblasts (MEFs) before and during adaptation to cell culture conditions. Matched expression data is deposited under accession: E-MTAB-3172
ORGANISM(S): Mus musculus 
2014-12-17 | E-MTAB-3176 | biostudies-arrayexpress
TranscriptomicsRapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems
5-hmC profiling of mouse embryonic fibroblasts before and during adaptation to cell culture conditions using hMeDIP-chip
ORGANISM(S): Mus musculus 
2014-12-17 | E-MTAB-3177 | biostudies-arrayexpress
TranscriptomicsProfiling of human CD4+ T subsets identifies a Th2-specific non-coding RNA GATA3-AS1
Host defense against diverse pathogens involves the recruitment and differentiation of CD4+ T effector subsets including T helper 1 (Th1), Th2, Th17 and induced regulatory T (Treg) cells. Surface phenotype studies have revealed subset-specific surface markers for the identification and purification ...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-43005 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 2)
Medical research focuses on disease-specific genes. By contrast, here we systematically examined the roles of shared genes for disease susceptibility and as therapeutic and diagnostic targets. Meta-analysis of all published disease-related genome-wide association studies (GWAS) showed that T helper ...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-44964 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 1)
Medical research focuses on disease-specific genes. By contrast, here we systematically examined the roles of shared genes for disease susceptibility and as therapeutic and diagnostic targets. Meta-analysis of all published disease-related genome-wide association studies (GWAS) showed that T helper ...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-44956 | biostudies-arrayexpress
GenomicsRapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems (hmeDIP-seq)
5hmC profiling of mouse embryonic fibroblasts before and during adaptation to cell culture conditions using 5hmC-Seq. Related data sets for this study have also been deposited in ArrayExpress under accessions E-MTAB-3172 (expression profiling by microarray), E-MTAB-3176 (methylation profiling of 5-m...
ORGANISM(S): Mus musculus 
2014-12-19 | E-MTAB-3183 | biostudies-arrayexpress
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