Profiling of human CD4+ T subsets identifies a Th2-specific non-coding RNA GATA3-AS1

ABSTRACT: Host defense against diverse pathogens involves the recruitment and differentiation of CD4+ T effector subsets including T helper 1 (Th1), Th2, Th17 and induced regulatory T (Treg) cells. Surface phenotype studies have revealed subset-specific surface markers for the identification and purification of human primary CD4+ T effector subsets. In the present study, we aimed to characterize the mRNA and large intergenic non-coding RNA (lincRNA) expression differences between human primary CD4+ T effector subsets and identify potential subset-specific genes. To achieve this goal, mRNA and lincRNA microarray profiling of flow cytometry-sorted human primary Th1, Th2, Th17 and Treg cells was performed. Principal component and pathway analyses revealed subset-specific gene expression patterns. A Th2

ORGANISM(S): Homo sapiens

SUBMITTER: Hui Wang 

PROVIDER: E-GEOD-43005 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress