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ModelsLorenz2026 - Wright-Fisher model with negative frequency-dependent selection (NFDS) for vaccine-replacement dynamics in S. pneumoniae
A compartmental Wright-Fisher model that describes the replacement dynamics in Streptococcus pneumoniae populations after the introduction of vaccines. Free parameters in the model are vaccine impact, negative frequency-dependent selection (NFDS), and immigration rate.
2026-09-27 | MODEL2609210001 | BioModels
GenomicsVaccines_and_the_evolution_of_antibiotic_resistance__elucidating_transmission_mechanisms_and_public_health_impact_using_deep_sequencing_of_Streptococcus_pneumoniae_and_mathematical_models
Vaccines_and_the_evolution_of_antibiotic_resistance__elucidating_transmission_mechanisms_and_public_health_impact_using_deep_sequencing_of_Streptococcus_pneumoniae_and_mathematical_models
PRJEB44545 | ENA
Genomicsgenotyped_bacterial_meningitis
This study includes 1146 samples of host genotyping data (genotyped) from Illumina Omni arrays. Samples were collected from adults (>16 yrs) patients with CSF confirmed bacterial meningitis in the Netherlands between 2006 and 2015. Metadata includes patient outcome, species of bacteria, and for 4...
EGAD00010002328 | EGA
Genomicsimputed_bacterial_meningitis
This study includes 1146 samples of host genotyping data (imputed) from Illumina Omni arrays, using https://imputation.sanger.ac.uk/ with the Haplotype Reference Consortium v1.1. Samples were collected from adults (>16 yrs) patients with CSF confirmed bacterial meningitis in the Netherlands betwe...
EGAD00010002327 | EGA
GenomicsHost genotyping data from Dutch adult bacterial meningitis patients and linked bacterial genome sequences
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. This st...
EGAS00001005993 | EGA
TranscriptomicsComparative genomic hybridization of Clostridium sporogenes and Clostridium botulinum strains
Clostridium botulinum is a heterogeneous Gram-positive species that comprises four genetically and physiologically distinct groups of bacteria that share the ability to produce botulinum neurotoxin, the most poisonous toxin known to man, and the causative agent of botulism, a severe disease of human...
ORGANISM(S): Clostridium botulinum 
2007-05-23 | E-TABM-264 | biostudies-arrayexpress
Genomicsena-DATASET-CRUK-CI-16-05-2016-12:25:56:672-139 - samples
Targeted sequencing of 173 genes in 2433 primary breast tumours. Data includes 2433 tumour samples, 523 adjacent normal (breast) samples and 127 blood samples. Libraries were prepared with Illumina's Nextera custom enrichment kit targetting all the exons of the most frequently mutated breast cance...
EGAD00001002115 | EGA
GenomicsMETABRIC: Data from Pereira et al (2016), The somatic mutation profiles of 2433 breast cancers refine their genomic and transcriptomic landscapes. Nat Comms 7.
The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study, we sequence 173 genes in 2433 primary breast tumours that have copy number aberration (CNA), gene expression, and long-term clinical follow-u...
EGAS00001001753 | EGA
GenomicsMeningene researchers data access committee
Data Access Committee EGAC00001002513
EGAC00001002513 | EGA
GenomicsATD
WTCCC1 project Autoimmune Thyroid Disease (ATD) samples
EGAD00000000011 | EGA
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