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TranscriptomicsBenzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient male mice
DNA damage induced by benzo(a)pyrene may lead to the formation of mutations and as a consequence to the development of diseases. However, it is uncertain whether benzo(a)pyrene causes heritable mutations in male germ cells, which would increase health risks in offspring. In a previous study, benzo(a...
ORGANISM(S): Mus musculus 
2010-08-23 | E-GEOD-17979 | biostudies-arrayexpress
TranscriptomicsFunctional categorization of transcriptome in the species Symphysodon aequifasciatus Pellegrin 1904 (Perciformes: Cichlidae) exposed to benzo[a]pyrene and phenanthrene
This study aims to evaluate the transcriptome alterations, through cDNA libraries, associated with the effects of the combination of two PAHs, benzo[a]pyrene (0.5M-NM-
ORGANISM(S): Symphysodon aequifasciata 
2013-12-09 | E-GEOD-51149 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response to benzo[a]pyrene treatment in HepG2 cells
This SuperSeries is composed of the following subset Series: GSE36242: Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells (RNA-Seq) GSE36243: Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells (Affymetrix) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-36244 | biostudies-arrayexpress
ProteomicsGlutathione S-transferase induction after exposure to benzo[a]pyrene
Benzo[a]pyrene induction of glutathione S-transferases, an activity-based protein profiling investigation
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD010610 | Pride
Gsh Mouse Polycyclic aromatic hydrocarbons Gst Glutathione Pah Benzo[a]pyrene B[a]p 
TranscriptomicsDynamic liver transcriptome response of Xenopus tropicalis to benzo[a]pyrene
Chronological RNA-seq of comparison of liver from xenopus tropicalis exposed or not to benzo[a]pyrene (10ﾵg/L)
ORGANISM(S): Xenopus tropicalis 
2014-08-18 | E-MTAB-2444 | biostudies-arrayexpress
TranscriptomicsBenzo[a]pyrene response in primary mouse hepatocytes
Gene expression changes to several concentrations of benzo[a]pyrene in primary hepatocytes of wildtype and Xpa-/-p53+/- mice
ORGANISM(S): Mus Musculus 
2011-08-11 | E-TABM-1139 | biostudies-arrayexpress
TranscriptomicsSub-chronic forestomach transcriptional response in adult male MutaTMMouse following oral exposure to benzo(a)pyrene
Benzo(a)pyrene is a well-established human carcinogen in humans and rodents. In the present study, we sought to determine the dose- and time-dependent changes in gene expression upon oral exposure to benzo(a)pyrene. Adult male MutaTMMouse were exposed to three doses of benzo(a)pyrene or vehicle cont...
ORGANISM(S): Mus musculus 
2013-09-27 | E-GEOD-43438 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response to benzo[a]pyrene treatment in HepG2 cells (Affymetrix)
Whole-genome transcriptome measurements are pivotal for characterizing carcinogenic mechanisms of chemicals and predicting toxic classes, such as genotoxicity, from in vitro and in vivo assays. DNA microarrays have evolved as the gold standard for this purpose. In recent years deep sequencing techno...
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-36243 | biostudies-arrayexpress
TranscriptomicsPulmonary gene expression in MutaTMMouse orally gavaged with three doses of benzo(a)pyrene and vehicle control
In this study, we investigate mRNA profiles in lung of mice exposed to benzo(a)pyrene. Male mice were exposed to three doses (25, 50, and 75 mg/kg/day BaP) for 28 days and profiles were examined three days post-exposure. Our analyses reveal that BaP causes pulmonary specific cellular transformation ...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-35718 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human amnion epithelial FL cells treated with the carcinogen BPDE at low concentration
The environmental carcinogen, (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), causes bulky-adduct DNA damages, triggers certain signaling pathways, and elicits gene expression changes. Here, we focused on the temporal gene expression changes induced by a low concentration (0.05 µM) BPDE in hum...
ORGANISM(S): Homo sapiens 
2009-01-14 | E-GEOD-10979 | biostudies-arrayexpress
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