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TranscriptomicsNatalizumab exerts direct signaling capacity and supports a pro-inflammatory phenotype in some patients with multiple sclerosis
Natalizumab is a recombinant monoclonal antibody raised against integrin alpha-4 (CD49d). It is approved for the treatment of patients with multiple sclerosis (MS), a chronic inflammatory autoimmune disease of the CNS. Natalizumab blocks leukocyte extravasation across the blood-brain barrier by inhi...
ORGANISM(S): Homo sapiens 
2015-05-02 | E-GEOD-37783 | biostudies-arrayexpress
TranscriptomicsPlant thermospermine-specific polyamine oxidases have a crucial role in vascular development and stem growth and were acquired from Metazoan(s) at non-vascular plant stage
Arabidopsis thaliana polyamine oxidase 5 gene (AtPAO5) functions as a thermospermine (T-Spm) oxidase. Aerial growth of its knock-out mutant (Atpao5-2) is significantly repressed by low dose(s) of T-Spm but not by other polyamines. Massive analysis of 3’-cDNA ends (MACE) was performed. Cell wall, l...
ORGANISM(S): Arabidopsis thaliana 
2016-02-22 | E-GEOD-69510 | biostudies-arrayexpress
TranscriptomicsNFATc1 controls the survival, function and suppressive capacity of B lymphocytes upon B cell receptor stimulation
Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ ...
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-21063 | biostudies-arrayexpress
UnknownNet Benefit of Early Anticoagulation for Stroke With Atrial Fibrillation: Post Hoc Analysis of the ELAN Randomized Clinical Trial.
Not available
S-EPMC11775740 | biostudies-literature
UnknownEarly vs Late Anticoagulation in Minor, Moderate, and Major Ischemic Stroke With Atrial Fibrillation: Post Hoc Analysis of the ELAN Randomized Clinical Trial.
Not available
S-EPMC11134281 | biostudies-literature
UnknownTarget ranges of oxygen saturation in extremely preterm infants.
Not available
S-EPMC2891970 | biostudies-literature
UnknownEarly CPAP versus surfactant in extremely preterm infants.
Not available
S-EPMC3071534 | biostudies-literature
UnknownGenome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.
Not available
S-EPMC11071577 | biostudies-literature
UnknownGenome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.
Not available
S-EPMC12165847 | biostudies-literature
UnknownPrediction of bronchopulmonary dysplasia by postnatal age in extremely premature infants.
Not available
S-EPMC3136997 | biostudies-literature
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