Smith2009 - RGS mediated GTP hydrolysis
This model is described in the article:
Dual positive and negative regulation of GPCR signaling by GTP hydrolysis.
Smith B, Hill C, Godfrey EL, Rand D, van den Berg H, Thornton S, H...
Mutations in the acid β-glucocerebrosidase (GBA1) gene, responsible for the lysosomal storage disorder Gaucher’s disease (GD), are the strongest genetic risk factor for Parkinson’s disease (PD) known to date. To elucidate the mechanisms underlying neurodegeneration in these patients, we generate...