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TranscriptomicsHistone acetylation and DNA demethylation of T-cells result in an anaplastic large cell lymphoma-like phenotype.
A characteristic feature of anaplastic large cell lymphoma (ALCL) is the significant reduction of the T-cell expression program despite its T-cell origin, a finding very similar to the loss of B-cell identity of classical Hodgkin lymphoma (cHL). Previously we demonstrated that epigenetic mechanisms ...
ORGANISM(S): Homo sapiens 
2012-08-19 | E-GEOD-26101 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation
CD8+ T cells play a critical role in the immune response to viral pathogens. Persistent human CMV (HCMV) infection results in a strong increase in the number of virus-specific, quiescent effector-type CD8+ T cells with constitutive cytolytic activity, but the molecular pathways involved in the ind...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-24151 | biostudies-arrayexpress
TranscriptomicsAntigen specific human conventional T cells (CD154+) or regulatory T cells (CD137+) directed agains A. fumigatus or Birch pollen lysate isolated from Birch pollen allergic patients or healthy controls.
Foxp3+ regulatory T cells (Treg) play a central role for tolerance against self and innocuous environmental antigens. However, the role of antigen-specificity for Treg-mediated tolerance is only incompletely understood. Here we show by direct ex vivo characterization of human CD4+ T cells, that the ...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-77018 | biostudies-arrayexpress
TranscriptomicsTCF1 is required for the differentiation of T follicular helper (TFH) cells during viral infections
TFH and Th1 cells generated after viral or intracellular bacterial infections are critical for the control of infections and the development of immunological memories. However, the mechanisms that govern the choice of activated CD4 T cells to the two alternative fates remain unclear. Here, we found ...
ORGANISM(S): Mus musculus 
2015-09-18 | E-GEOD-65660 | biostudies-arrayexpress
TranscriptomicsComprehensive analysis of miRNA expression in T-cell subsets of Rheumatoid arthritis patients and healthy controls reveals defined miRNA signatures of naive and memory Tregs
Disturbed expression of microRNAs (miRNAs) in regulatory T-cells (Tregs) leads to development of autoimmunity in experimental mouse models. However, the miRNA expression signature characterizing Tregs of autoimmune diseases, such as rheumatoid arthritis (RA) has not been determined yet. Moreover, th...
ORGANISM(S): Homo sapiens 
2014-01-22 | E-GEOD-50646 | biostudies-arrayexpress
ProteomicsActivated neutrophils exert myeloid-derived suppressor cell activity, damaging T cells beyond repair
Myeloid-derived suppressor cells (MDSCs) have the capacity to suppress T cell-mediated immune responses, and impact clinical outcome of cancer, infections and transplantation settings. Although MDSCs were initially described as bone-marrow-derived immature myeloid cells (either monocytic [m-MDSC] or...
ORGANISM(S): Homo sapiens (Human) 
2020-05-07 | PXD010508 | Pride
Large t cells Mdsc Small t cells 
GenomicsDifferential gene expressionin cMet-enriched T cell populations
Differential gene expressionin cMet-enriched T cell populations
PRJNA773097 | ENA
ProteomicsLow-Density Lipoprotein Receptor fuels the cellular cholesterol-mTORC1 axis required for CD8+ T cell activation
In this study, the contribution of cholesterol uptake by the low-density-lipoprotein receptor (LDLR) in the metabolic reprogramming of activated T cells was investigated at proteome level by mass-spectrometry-assisted shotgun proteomics.
ORGANISM(S): Mus musculus (Mouse) 
2022-09-20 | PXD030365 | Pride
Mtorc1 Cholesterol Lfq Cd8+ Ldlr 
GenomicsEpigenetic modifications induced by Blimp-1 regulate CD8+ T cell memory progression during acute virus infection
Blimp-1 regulates the overall accumulation of virus-specific CD8+ T cells during acute viral infections. Increased proliferation and survival of Blimp-1-deficient CD8+ T cells is promoted by persistent cytokine responsiveness, resulting from sustained expression of CD25 and CD27. Knockdown of thes...
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-48358 | biostudies-arrayexpress
TranscriptomicsExperimental identification of apoptosis-associated miR-21 target genes in Jurkat T-cells using a high-throughput experimental approach
MiR-21 is an important suppressor of T-cell apoptosis that is also widely overexpressed in many types of cancers. The exact mechanisms related to the anti-apoptotic effect of miR-21 is not well understood. In this study, we applied AGO2 RNA Immunoprecipitation followed by gene expression profiling (...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-85116 | biostudies-arrayexpress
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