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TranscriptomicsTranscriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils
The role of myeloid cells in supporting cancer growth is well established. Most work has focused on myeloid-derived suppressor cells (MDSC) that accumulate in tumor-bearing animals, but tumor-associated neutrophils (TAN) are also known to be capable of augmenting tumor growth. However, little is kno...
ORGANISM(S): Mus musculus 
2013-01-04 | E-GEOD-43254 | biostudies-arrayexpress
TranscriptomicsExpression data from granulocytic MDSC (G-MDSC) and neutrophils
Myeloid derived suppressor cells (MDSC) playing the immune suppressive roles in tumor bearing host consists of two major subsets of granulocytic and monocytic cells. Granulocytic MDSC (G-MDSC) express CD11b+ Gr-1high Ly6G+ Ly6Clow and produce high level of reactive oxygen species (ROS). Interestingl...
ORGANISM(S): Mus musculus 
2011-03-10 | E-GEOD-24102 | biostudies-arrayexpress
ProteomicsHigh-throughput screening and proteomic characterization of compounds targeting myeloid-derived suppressor cells
Myeloid-derived suppressor cells are a heterogeneous cell population of incompletely differentiated immune cells. They are known for suppressing T cell activity and are implicated in multiple chronical diseases, which makes them an attractive drug target for the pharmaceutical industry. Here, we dif...
ORGANISM(S): Homo sapiens (Human) 
2023-08-15 | PXD043407 | Pride
Mdsc Proteomics Screening Ptm Phosphorylation 
ProteomicsImmunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata
We have demonstrated therapeutic efficacy of MDSC in mouse Alopecia Areata (AA). In the same AA model, we now asked whether MDSC exosomes (MDSC-Exo) can replace MDSC. MDSC-Exo from bone marrow cells (BMC) cultures of healthy donors could substantially facilitate treatment. With knowledge on MDSC-Exo...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-08-16 | MSV000082825 | MassIVE
ProteomicsProteomic profiling of extracellular vesicles from cancer-associated fibroblast-induced myeloid-derived suppressor cells and related cell types
Cancer-associated fibroblast (CAF) promote immune suppression in the tumor microenvironment by polarizing monocytes to myeloid-derived suppressor cells (MDSC) that potently suppress T-cell function. Using a patient-derived coculture system, we found that extracellular vesicles (EV) released by CAF-i...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD035248 | Pride
Mdsc Stroma Coculture Exosome Caf 
ProteomicsCell surface proteome profiling of cancer-associated fibroblast-induced myeloid-derived suppressor cells and related cell types
Cancer-associated fibroblasts (CAF) promote immune suppression in the tumor microenvironment by polarizing monocytes to myeloid-derived suppressor cells (MDSC) that potently suppress T-cell function. Using a patient-derived coculture system, we profiled the cell surface proteome of CAF-induced MDSC ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD035259 | Pride
Mdsc Stroma Coculture Caf Myeloid 
ProteomicsDetermining qualitative and quantitative differences in the protein, mRNA and miRNA content of myeloid-derived suppressor cells and their released exosomes
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that accumulate in the tumor microenvironment of most cancer patients. There MDSCs suppress both adaptive and innate immune responses, hindering immunotherapies. Moreover, many cancers are accompanied by inflammation, a processes th...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-17 | PXD006204 | Pride
Myeloid-derived suppressor cells Exosomes Spectral counting Lc-ms/ms 
GenomicsExpression data from in vitro differentiated MDSC
Expression data from in vitro differentiated MDSC
PRJNA623778 | ENA
ProteomicsProteomic Pathway Analysis Reveals Inflammation Increases Myeloid-Derived Suppressor Cell Resistance to Apoptosis
Myeloid derived suppressor cells (MDSC) accumulate in patients and animals with cancer where they mediate systemic immune suppression and obstruct immune based cancer therapies. To determine how inflammation enhances MDSC levels and activity we used mass spectrometry to identify proteins produced by...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-06-25 | MSV000082500 | MassIVE
TranscriptomicsMDSC exacerbate acute hepatitis, mature and loose suppressor function CD40 dependent
Myeloid-derived suppressor cells (MDSC) represent a heterogeneous population of immature myeloid cells that accumulate in blood, liver, spleen and tumors upon chronic inflammation and tumor development in patients and mice. Acute hepatitis is characterized by a fast infiltration of inflammatory cell...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-50949 | biostudies-arrayexpress
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