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MetabolomicsSingle-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance
Multi-drug resistance (MDR) is an almost inevitable end point of cancer therapy, driving rapid tumor progression, yet its evolutionary logic remains unclear because MDR tumors are rarely resected. Using paired therapy-naive and MDR melanoma specimens from a clinical trial, integrated with single-cel...
2027-08-13 | MTBLS15322 | MetaboLights
TranscriptomicsGene expression profiling of tumor stroma in human intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is the second most common type of primary cancer in the liver. ICC is an aggressive cancer with poor prognosis and limited therapeutic strategies. The identification of new drug targets and prognostic biomarkers is an important clinical challenge for ICC. The pr...
ORGANISM(S): Homo sapiens 
2013-06-21 | E-GEOD-45001 | biostudies-arrayexpress
TranscriptomicsExpression data from WT, Crebbp+/- and Ep300+/- bone marrow stroma
We found that the bone marrow microenvironment of Crebbp+/- mice was unable to properly maintain the immature stem - and progenitor pools. Instead, it stimulates myeloid differentiation that progresses into a myeloproliferative-like disease. Since CREBBP is a transcriptional co-activator, we used ge...
ORGANISM(S): Mus musculus 
2011-03-01 | E-GEOD-24773 | biostudies-arrayexpress
ProteomicsComparative Proteomics Reveals Prolonged Corneal Preservation Impaired Ocular Surface Immunity Accompanied with Fibrosis in Human Stroma
Cornea transplantation is a widely performed procedure globally. However, storing donor corneas for extended periods in Optisol-GS storage medium at 4 ℃ can lead to reduced endothelial cell viability, causing severe stromal edema and opacification. This negatively impacts transplantation success. Th...
ORGANISM(S): Homo Sapiens (human) 
2024-09-29 | PXD045907 | JPOST Repository
TranscriptomicsGene expression profiles of reactive stroma in prostate cancer
This is an analysis of stroma from 17 Grade 3 reactive stroma prostate cancer tissues and matched normal peripheral zone tissues. Keywords: two group comparison Laser capture microdissection and expression array analysis of stroma from 17 Grade 3 reactive stroma prostate cancer tissues and matched ...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-11682 | biostudies-arrayexpress
ProteomicsProteomics of HS-5 and NKTert stroma cells
Comparison of the proteome of the human bone marrow stroma cell lines NKTert and HS-5.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027945 | Pride
Stroma hs-5 nktert proteomics 
ProteomicsMSE quantified stroma proteome
Label-free protein quantification has developed into an attractive alternative to isotopic labeling for the quantification of proteins by mass spectrometry. Recently, the suite of label-free quantification strategies was expanded by LC-MSE–based absolute and relative protein quantification. We repor...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-04-14 | PXD000446 | Pride
Meta-analysis Cloroplast stroma Quantitative lc-hdmse Normalization Arabidopsis thaliana 
TranscriptomicsTranscription profiling by array of human stromal cells cultured with or without 3D BPH-1 prostate epithelial cells
BPH-1 prostate epithelial cells when cultured in Matrigel form 3D acini which closely recapitulate the tissue architecture of the prostate. The presence of primary stroma increases epithelial adhesions and causes changes in morphology. To identify the stromal signals which control actin/cadherin dy...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-MEXP-2657 | biostudies-arrayexpress
TranscriptomicsTranscriptome of the bone metastasis associated stroma
The reciprocal interaction between cancer cells and the tissue-specific stroma is critical for primary and metastatic tumor growth progression. Prostate cancer cells colonize preferentially bone (osteotropism), where they alter the physiological balance between osteoblast-mediated bone formation and...
ORGANISM(S): Mus musculus 
2014-12-09 | E-GEOD-22813 | biostudies-arrayexpress
ProteomicsProteoMixture: A Cell Deconvolution Tool for Bulk Tissue Proteomics Data
Numerous multi-omic investigations of cancer tissue have documented varying and poor pairwise transcript:protein quantitative correlations and most deconvolution tools aiming to predict cell type proportions (cell admixture) have been developed and credentialed using transcript-level data alone. To ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-12 | PXD044157 | Pride
Laser microdissection High grade serous ovarian cancer Proteomics Stroma signature Immune signature Cellular admixture Tumor signature 
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