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TranscriptomicsDefining precision probes which differentiate between the activity of type I and type II interferons.
To define probes which differentiate between the activity of type I or type II IFN, a human submandibular gland (HSG) cell line was cultured for 48 hours in the absence or presence of IFNa or IFNg. Gene expression was assayed at 4, 12, 24 or 48 hours and was compared to gene expression in untreated ...
ORGANISM(S): Homo sapiens 
2012-10-08 | E-GEOD-41291 | biostudies-arrayexpress
TranscriptomicsExpression data in PD-L1 positive and PD-L1 negative human melanoma samples
Blocking the PD-1/PD-L1 immunosuppressive pathway has shown promise in the treatment of certain cancers including melanoma. This study investigates differences in the gene expression profiles of human melanomas that do or do not display the immunosuppressive protein PD-L1. Further understanding of g...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-65041 | biostudies-arrayexpress
TranscriptomicsMolecular mechanism underlying the regulatory specificity of a Drosophila homeodomain protein that specifies myoblast identity
A subfamily of Drosophila homeodomain (HD) transcription factors (TFs) controls the identities of individual muscle founder cells (FCs). However, the molecular mechanisms by which these TFs generate unique FC genetic programs remain unknown. To investigate this problem, we first applied genome-wide ...
ORGANISM(S): Drosophila melanogaster 
2012-01-28 | E-GEOD-35380 | biostudies-arrayexpress
TranscriptomicsExpression data in human renal cell carcinoma samples from patients who did or did not respond to anti-PD-1 (Nivolumab) immunotherapy
Pre-treatment tumor expression of PD-L1 has been shown to correlate with favorable clinical outcomes following PD-1 blocking therapies. However, the majority of patients with PD-L1+ tumors do not respond to treatment. With the goal of obtaining insights into the mechanisms underlying the response to...
ORGANISM(S): Homo sapiens 
2016-08-04 | E-GEOD-67501 | biostudies-arrayexpress
TranscriptomicsAngiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in a murine model
TGFβ inhibition attenuates chronic cigarette smoke induced lung injury and rescues lung architecture. AKR/J mice were exposed to Cigarette Smoke (CS) for a period of two months. Some animals received a treatment of Losartan (.6gr/L) orally while exposed (CS Los). These two groups are to be compare...
ORGANISM(S): Mus musculus 
2011-12-30 | E-GEOD-33561 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of humuan peripheral blood mononuclear cells stimulated with interleukin-12 and unstimulated controls
The cytokine interleukin-12 (IL-12) is known to play a central role in adaptive and innate immunity. We employed microarray analysis of IL-12 induced gene expression to provide further insights into its effects on immune response. Experiment Overall Design: PBMC's were isolated from 7 healthy NIH bl...
ORGANISM(S): Homo sapiens 
2008-11-21 | E-GEOD-12839 | biostudies-arrayexpress
TranscriptomicsMyeloid cells are enriched in tonsillar crypts providing insight into the host tropism of HPV
Viruses are the second leading cause of cancer worldwide, and human papillomavirus (HPV)-associated head and neck cancers are increasing in incidence in the United States. HPV preferentially infects the crypts of the tonsils rather than the surface epithelium. The present study sought to characteriz...
ORGANISM(S): Homo sapiens 
2021-06-18 | GSE155139 | GEO
GenomicsHomo sapiens
Defining precision probes which differentiate between the activity of type I and type II interferons.
PRJNA176459 | ENA
TranscriptomicsAssessment of chemical mixtures and ground water effects on Daphnia magna transcriptomics
Small organisms can be used as biomonitoring tools to assess chemicals in the environment. Chemical stressors are especially hard to assess and monitor when present as complex mixtures. Here, Daphnia magna were exposed for 24 hours to five different munitions constituents 2,4,6-trinitrotoluene (TNT)...
ORGANISM(S): Daphnia magna 
2011-06-22 | E-GEOD-30163 | biostudies-arrayexpress
TranscriptomicsErythroid-Specific Transcriptional Changes in PBMCs from Pulmonary Hypertension Patients
The hypothesis tested in this study was that chronic exposure of PBMCs to a hypertensive environment in remodeled pulmonary vessels would be reflected by specific transcriptional changes in these cells. The transcript profiles of PBMCs from 30 idiopathic pulmonary arterial hypertension patients (IPA...
ORGANISM(S): Homo sapiens 
2012-04-29 | E-GEOD-33463 | biostudies-arrayexpress
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