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TranscriptomicsVariation in homeodomain DNA-binding revealed by high-resolution analysis of sequence preferences
Most homeodomains are unique within a genome, yet many are highly conserved across vast evolutionary distances, implying strong selection on their precise DNA-binding specificities. We determined the binding preferences of the majority (168) of mouse homeodomains to all possible 8-base sequences, re...
ORGANISM(S): Mus musculus 
2010-06-26 | E-GEOD-11239 | biostudies-arrayexpress
MetabolomicsParenteral Nutrition as a Source of Xenobiotic Exposure in Preterm Infants in a Single-Center Case Study

In premature infants, successful ex utero maturation depends on endogenous and exogenous stimuli. Chemical insults during this period may impact long-term development. Given immature hepatic biotransformation, parenteral xenobiotic exposure may be of particular toxicological relevance. We conduct...

2026-10-22 | MTBLS14273 | MetaboLights
TranscriptomicsMolecular mechanism underlying the regulatory specificity of a Drosophila homeodomain protein that specifies myoblast identity
A subfamily of Drosophila homeodomain (HD) transcription factors (TFs) controls the identities of individual muscle founder cells (FCs). However, the molecular mechanisms by which these TFs generate unique FC genetic programs remain unknown. To investigate this problem, we first applied genome-wide ...
ORGANISM(S): Drosophila melanogaster 
2012-01-28 | E-GEOD-35380 | biostudies-arrayexpress
TranscriptomicsA library of yeast transcription factor motifs
The sequence specificity of DNA-binding proteins is the primary mechanism by which the cell recognizes genomic features. Here, we describe systematic determination of yeast transcription factor DNA-binding specificities. We obtained binding specificities for 112 DNA-binding proteins representing 19 ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-26 | E-GEOD-12349 | biostudies-arrayexpress
MetabolomicsMetabolic characterization of the natural progression of chronic hepatitis B (Biogenic amine and Acyl-carnitine assays)
Background: Worldwide, over 350 million people are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing progressive liver diseases. The confinement of HBV replication to the liver, which also acts as the central hub for metabolic and nutritional regulation, e...
2016-06-06 | MTBLS280 | MetaboLights
MetabolomicsMetabolic characterization of the natural progression of chronic hepatitis B (Lipid assays)
Background: Worldwide, over 350 million people are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing progressive liver diseases. The confinement of HBV replication to the liver, which also acts as the central hub for metabolic and nutritional regulation, e...
2016-06-06 | MTBLS279 | MetaboLights
TranscriptomicsSite-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response
Physiologically, Notch signal transduction plays a pivotal role in differentiation; pathologically, Notch signaling contributes to the development of cancer. Transcriptional activation of Notch target genes involves cleavage of the Notch receptor in response to ligand binding, production of the Notc...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-62528 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Kir6.1-deficient heart following LPS challenge
KATP opposes depolarization of cells in the heart, smooth muscle, and other tissues by permitting the efflux of potassium ions and this efflux is evidently required to prevent unopposed vasoconstriction and insufficiency of coronary artery blood flow triggered by one or more cytokines induced in res...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7605 | biostudies-arrayexpress
TranscriptomicsSystems Modeling of the Rho Signaling Network
Describing the architecture of robust, nonlinear cell signaling networks is essential to gain a predictive understanding of cellular behavior. The structure of the Drosophila Rho-signaling network, comprised of Rho-family GTPases, RhoGTP Exchange Factors (RhoGEFs), and RhoGTPase Activating Proteins...
ORGANISM(S): Drosophila melanogaster 
2012-12-31 | E-GEOD-18307 | biostudies-arrayexpress
TranscriptomicsDissection of the F. graminearum transcriptome in response to an active or passive host identifies new pathogen-specific genes.
Comparing RNA Seq- Data of all three sample types- pathogenic growth, saprophytic growth on same plant substrate, axenic growth under starvation after consumption of the mycotoxin inducing nitrogen source L-ornithine- allows to distinguish between genes whose transcription is affected by nutrient st...
ORGANISM(S): Fusarium graminearum PH-1 
2016-04-01 | E-GEOD-72124 | biostudies-arrayexpress
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