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GenomicsRegions of Focal DNA Hypermethylation and Long-Range Hypomethylation in Colorectal Cancer Coincide with Nuclear Lamina-Associated Domains
Extensive changes in DNA methylation are common in cancer and may contribute to oncogenesis through transcriptional silencing of tumor suppressor genes. Genome-scale studies have yielded important insights into these changes, but have focused on CpG islands or gene promoters. We used whole-genome bi...
ORGANISM(S): Homo sapiens 
2011-09-26 | E-GEOD-32399 | biostudies-arrayexpress
GenomicsGenome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion.
Runx2 is a metastatic transcription factor (TF) increasingly expressed during prostate cancer (PCa) progression. Using PCa cells conditionally expressing Runx2, we previously identified Runx2-regulated genes with known roles in epithelial-mesenchymal transition, invasiveness, angiogenesis, extracel...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-33889 | biostudies-arrayexpress
GenomicsEpigenetic Profiling of Human Colorectal Cancer

DNA methylation, together with chromatin modifications, constitute the epigenome that functions to regulate gene expression and genome integrity. DNA methylation alterations are ubiquitous in human cancers, as many genes acquire DNA methylation in a cancer-specific manner. DNA methylation at thes...

phs000385.v1.p1 | EGA
GenomicsGender-specific post-natal demethylation and establishment of epigenetic memory
DNA methylation patterns are set up in a relatively fixed programmed manner during normal embryonic development and are then stably maintained. Using genome-wide analysis, we have discovered a postnatal pathway involving gender-specific demethylation that occurs exclusively in the male liver. This...
ORGANISM(S): Homo sapiens 
2015-05-03 | E-GEOD-60012 | biostudies-arrayexpress
TranscriptomicsFunctional enhancers at the gene-poor 8q24 cancer-linked locus
Multiple discrete regions at 8q24 were recently shown to contain alleles that predispose to many cancers including prostate, breast, and colon. These regions are far from any annotated gene and their biological activities have been unknown. Here we profiled a 5-megabase chromatin segment encompassin...
ORGANISM(S): Homo sapiens 
2009-12-18 | E-GEOD-19561 | biostudies-arrayexpress
UnknownPrediction of disability-free survival in healthy older people.
Not available
S-EPMC9213595 | biostudies-literature
UnknownEffect of Aspirin on Disability-free Survival in the Healthy Elderly.
Not available
S-EPMC6426126 | biostudies-literature
UnknownEffect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.
Not available
S-EPMC6289056 | biostudies-literature
UnknownEffect of Aspirin on All-Cause Mortality in the Healthy Elderly.
Not available
S-EPMC6433466 | biostudies-literature
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