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TranscriptomicsDNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity
DNA replication is sensitive to damage in the template. To bypass lesions and complete replication, cells activate recombination-mediated (error-free) and translesion synthesis-mediated (error-prone) DNA damage tolerance pathways. Crucial for error-free DNA damage tolerance is template switching, wh...
ORGANISM(S): Saccharomyces cerevisiae 
2014-01-28 | E-GEOD-46260 | biostudies-arrayexpress
TranscriptomicsSenataxin associates with replication forks to protect fork integrity across RNAPII transcribed genes
Here we analysed the role of yeast Senataxin (Sen1) in coordinating replication with transcription and in protecting genome integrity. Senataxin is mutated in the two severe neurodegenerative diseases AOA2 and ALS4. We show that a fraction of Sen1/Senataxin DNA/RNA helicase associates with replicati...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-09 | E-GEOD-39139 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding of THO and Sub2 in Saccharomyces cerevisiae
THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis and prevents transcription-associated recombination. Whether or not it has a ubiquitous role in the genome is an open question. ChIP-chip studies reveal that the Hpr1 component of THO and the Sub2 RNA-dependent ATPase have gen...
ORGANISM(S): Saccharomyces cerevisiae 
2011-06-28 | E-GEOD-24960 | biostudies-arrayexpress
TranscriptomicsTop1 and Top2-mediated replication fork integrity
DNA topoisomerases solve topological problems during chromosome metabolism. We investigated where and when Top1 and Top2 are recruited on replicating chromosomes and how their inactivation affects fork integrity and DNA damage checkpoint activation. We show that, in the context of replicating chroma...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-8305 | biostudies-arrayexpress
UnknownIs neutropenia still the main risk factor for invasive aspergillosis? A contemporary university hospital retrospective cohort of invasive aspergillosis in neutropenic and non-neutropenic patients.
Not available
S-EPMC12032692 | biostudies-literature
UnknownReactogenicity to the mRNA-1273 Booster According to Previous mRNA COVID-19 Vaccination.
Not available
S-EPMC9414494 | biostudies-literature
UnknownFrequency, risk factors, and outcomes of hospital readmissions of COVID-19 patients.
Not available
S-EPMC8253752 | biostudies-literature
UnknownAssociation Between ABCB1 Genetic Variants and Persistent Chemotherapy-Induced Alopecia in Women With Breast Cancer.
Not available
S-EPMC7407317 | biostudies-literature
UnknownEuropean Registry on Helicobacter pylori management: Single-capsule bismuth quadruple therapy is effective in real-world clinical practice.
Not available
S-EPMC8259339 | biostudies-literature
UnknownEuropean Registry on Helicobacter pylori Management: Effectiveness of First and Second-Line Treatment in Spain.
Not available
S-EPMC7823881 | biostudies-literature
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