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TranscriptomicsCell-cycle regulation of cohesin stability along fission yeast chromosomes
Sister chromatid cohesion is mediated by cohesin but the process of cohesion establishment during S phase is still enigmatic. Recent data indicate that in mammalian cells, cohesin binding to chromatin is dynamic in G1 but becomes stabilized during S phase. Whether the regulation of chromosomal cohes...
ORGANISM(S): Schizosaccharomyces pombe 
2007-11-30 | E-GEOD-8450 | biostudies-arrayexpress
ProteomicsAdvantage of using scout-triggered multiple reaction monitoring mass spectrometry for robust quantification of host cell proteins in biotherapeutics matrices
The European and United States Pharmacopeias require the characterization and quantification of host cell proteins (HCPs) contaminating biological products, as these proteins pose a potential risk to clinical safety and product stability. The Enzyme-linked ImmunoSorbent Assay (ELISA) is currently th...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2026-02-23 | PXD066465 | Pride
Bioanalysis Biopharmaceutical characterization Host cell protein Analytical biochemistry Cho Chinese hamster ovary Hcp Antibody(s) 
UnknownDetection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives.
Not available
S-EPMC7724284 | biostudies-literature
UnknownGenome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy.
Not available
S-EPMC4879713 | biostudies-literature
UnknownCabozantinib, a New Standard of Care for Patients With Advanced Renal Cell Carcinoma and Bone Metastases? Subgroup Analysis of the METEOR Trial.
Not available
S-EPMC6804840 | biostudies-literature
TranscriptomicsDown-regulation of Interferon signature in systemic lupus erythematosus patients by active immunization with Interferon alpha-Kinoid extended follow-up
Interferon-alpha Kinoid (IFN-K) is a therapeutic vaccine composed of IFN-alpha2b coupled to a carrier protein. In a phase I/II placebo-controlled trial, we observed that IFN-K significantly decreases the IFN gene signature in whole blood RNA samples from SLE patients (see GSE39088). Here, we analyze...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-72754 | biostudies-arrayexpress
UnknownChitin-glucan supplementation improved postprandial metabolism and altered gut microbiota in subjects at cardiometabolic risk in a randomized trial.
Not available
S-EPMC9132890 | biostudies-literature
TranscriptomicsEffects of tocilizumab versus methotrexate therapy on gene expression profiles in the early rheumatoid arthrtis synovium
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease that is characterized by the presence of inflammatory cytokines, including interleukin-6 (IL-6). Here, we investigated the global molecular effects of Tocilizumab, an approved humanized anti-IL6 Receptor antibody, versu...
ORGANISM(S): Homo sapiens 
2013-12-30 | E-GEOD-45867 | biostudies-arrayexpress
UnknownImpact of centre volume, surgeon volume, surgeon experience and geographic location on reoperation after intramedullary nailing of tibial shaft fractures
Not available
S-EPMC8410470 | biostudies-literature
UnknownSix-month antibody response to SARS-CoV-2 in healthcare workers assessed by virus neutralization and commercial assays.
Not available
S-EPMC7803622 | biostudies-literature
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