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TranscriptomicsTranscription profiling of rat at pheochromocytoma cell line PC12 treated with trimethyltin at low and high doses
The rat pheochromocytoma cell line PC12 cells were cultured in complete DMEM till 80% confluence, then placed at 5000 cells per squared cm. Cells were then plated in 24-well plates for cell viability assay and in T75 flasks for RNA isolation. Medium was replaced with serum-free fresh medium for 12 ...
ORGANISM(S): Rattus norvegicus 
2009-04-29 | E-GEOD-5073 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of ALS skeletal muscle
Objective: to focus on the molecular mechanisms involved in the ALS related atrophy process that leads to selective wasting muscles . Design: gene expression profiling and real time PCR were performed on muscle biopsies
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-41414 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression profiling of human narcolepsy
Study objectives: The objectives of this study was perform the global gene expression profiling aimed at identifying differentially expressed genes in the circulating lympho-monocytes of NRLCP patients affected by Narcolepsy with Cataplexy (NRLCP). Based on the tight association to the HLA-DQB1*0602...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-21592 | biostudies-arrayexpress
TranscriptomicsMuscle expression of SOD1G93A modulates microRNA and mRNA expression pattern associated with the myelination process in the spinal cord of transgenic mice.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-71194 | biostudies-arrayexpress
TranscriptomicsEffect of s100b on lan5 cells
The human neuroblastoma cell line Lan5 cells were cultured in complete DMEM till 80% confluence, then placed at 60000 cells per squared cm. Cells were then plated in 24-well plates for cell viability assay and in T75 flasks for RNA isolation. Medium was replaced with serum-free fresh medium for 12 h...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-15218 | biostudies-arrayexpress
TranscriptomicsTranscriptional effects of LMP3 in MSC
Lim Mineralization Protein, splice variant-3 (LMP3) is known to induce osteoblast differentiation as a result of active modulation of selected molecules involved in the osteogenic cascade. LMP3 seems to act as an upstream modulator of osteogenic differentiation, although the complete network of mole...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-16614 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human quadriceps muscle of young Duchenne muscular dystrophy patients and age matched controls
Albeit increased serum CK level and abnormal muscle histology are always present, boys with DMD are phenotipically indistinguishable from the normal ones at birth and, in their first years of life, acquire early motor milestones at normal times. A clear defect in muscle function becomes generally ap...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6011 | biostudies-arrayexpress
TranscriptomicsMuscle expression of SOD1G93A modulates microRNA and mRNA expression pattern associated with the myelination process in the spinal cord of transgenic mice [microarray]
Expression profiling of lumbar spinal cord from MLC/SOD1G93A mice and age matched controls at 120 days of age. We used Affymetrix GeneChip Mouse Gene expression 2.0 st Array to determine differential gene expression. Samples were collected from mice MLC/SOD1G93A and controls FVB age matched at 4 mon...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-69582 | biostudies-arrayexpress
TranscriptomicsMuscle expression of SOD1G93A modulates microRNA and mRNA expression pattern associated with the myelination process in the spinal cord of transgenic mice [RT-PCR]
Expression profile of microRNA in lumbar spinal cord from MLC/SOD1G93A using Applied Biosystem Array Mouse MicroRNA A Card Lumbar Spinal Cord Ventral samples were collected from mice MLC/SOD1[G93A] and control FVB age matched at 4 month-old. Samples were collected for RNA extraction and analyzed on...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-71193 | biostudies-arrayexpress
TranscriptomicsThe multikinase inhibitor Sorafenib targets mitochondria and synergizes with glycolysis blockade for cancer cell killing.
Objective: identify novel and relevant aspects of Sorafenib action on liver cancer cells. We found that in rat hepatocholangiocarcinoma (LCSC-2) cells, exposure to the MEK/multikinase inhibitor sorafenib did not inhibit ERK phosphorylation nor induced appreciable cell death in the low micromolar ra...
ORGANISM(S): Rattus norvegicus 
2015-02-04 | E-GEOD-43053 | biostudies-arrayexpress
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