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ProteomicsInactivation of the response regulator AgrA has a pleiotropic effect on biofilm formation, pathogenesis and stress response in Staphylococcus lugdunensis
Staphylococcus lugdunensis is a coagulase-negative Staphylococcus that emerges as an important opportunistic pathogen. However, little is known about the regulation underlying the transition from commensal to virulent state. Based on knowledge of S. aureus virulence, we suspected that the agr quorum...
ORGANISM(S): Staphylococcus lugdunensis 
2022-02-22 | PXD028347 | Pride
Transcriptional regulation Staphylococcus lugdunensis Agra Agr system 
ProteomicsWhite body nanoLC ESI-MS/MS analysis in the cephalopod Sepia officinalis
Cephalopods, like other Protostomes, lack an adaptive immune system and only rely on an innate immune system. The main immune cells are haemocytes, able to respond to pathogens and external attacks. First reports based on morphological observations suggested that the white body located in the optic ...
ORGANISM(S): Sepia officinalis 
2020-07-10 | PXD017509 | Pride
Cuttlefish White body Esi-ms/ms 
ProteomicsAntibiofilm and antivirulence properties of 6-polyaminosteroid derivatives against antibiotic-resistant bacteria
The emergence of multi-drug resistant pathogens is a major public health problem, leading to rethink and innovate in our bacterial control strategies. Here, we explore the anti-biofilm and anti-virulence activities of nineteen 6-polyaminosterol derivatives (squalamine-based), presenting a modulation...
ORGANISM(S): Staphylococcus Aureus 
2023-12-20 | PXD048020 |
ProteomicsNicotinamide riboside modulates the reactive species interactome, bioenergetic status and proteomic landscape in a brain-region-specific manner
Nicotinamine riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+), has robust behavioral and cognitive benefits as well as effects alleviating neuroinflammation in AD mouse models. Gene expression studies hint benefitial induction of neuroprotective pathways for AD. However, the pr...
ORGANISM(S): Mus Musculus 
PXD053897 |
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