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ProteomicsSILAC-based quantification reveals modulation of the immunopeptidome in BRAF and MEK inhibitor-treated and resistant tumor cells
The immunopeptidome is constantly monitored by T cells to detect foreign or aberrant HLA peptides. It is highly dynamic and reflects the current cellular state, enabling the immune system to recognize abnormal cellular conditions, such as those present in cancer cells. To precisely determine how cha...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054097 | Pride
Kinase inhibitor resistance Immunopeptidomics Cancer Mass-spectrometry Cryptic peptides Mapk signaling Melanoma Lc-ms/ms 
ProteomicsExtending the Mass Spectrometry-Detectable Landscape of the Immunopeptidome by use of Restricted access Material
Mass spectrometry-based immunopeptidomics enables the comprehensive identification of major histocompatibility complex (MHC) peptides from cell culture as well as from tissue or tumor samples and is increasingly applied for the identification of tumor-specific and viral T-cell epitopes. Although mas...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-11-07 | PXD034017 | Pride
Immunopeptidomics Solid phase extraction Restricted access material 
ProteomicsLoss of p14 reduces immunogenicity in melanoma by affecting the peptide surface density via non-canonical Wnt signaling
CDKN2A and its two gene products p14 and p16 are one of the most frequently negatively altered gene loci (either by loss or mutation) in advanced melanoma accompanied by decreased T cell infiltration in melanoma. In this study, we shed light on the connection of the reduction of the CDKN2A gene prod...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046891 | Pride
Hla Human immunopeptidome Differnetiation antigen Melanoma 
UnknownNeurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula: A Randomized Clinical Trial.
Not available
S-EPMC10828950 | biostudies-literature
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