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GenomicsRecurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Follicular lymphoma (FL) is an incurable B-cell malignancy characterized by the t(14;18) and mutations in one or more components of the epigenome. Whilst frequent gene mutations in signaling pathways, including JAK-STAT, NOTCH and NF-κB, have also been defined, the spectrum of these mutations typic...
EGAS00001001190 | EGA
Genomicsena-DATASET-BCI-18-03-2015-12:48:54:303-380 - samples
Whole exome sequencing data of 5 patients diagnosed with FL that had undergone several relapse episodes without evidence of transformation
EGAD00001001301 | EGA
GenomicsBarts Cancer Institute - Follicular Lymphoma Whole Genome Sequencing Project Data Access Committee
Data Access Committee EGAC00001000086
EGAC00001000086 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-28-08-2015-09:49:06:632-229 - samples
RNA-sequencing data from teh hT-RPE-MycER cell line after MYC activation and after MINCR knock-down in conditions of MYC ON or OFF
EGAD00001001598 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-16-07-2015-15:45:02:488-51 - samples
Despite the established role of the transcription factor MYC in cancer, little is known about the impact of a new class of transcriptional regulators, the long non-coding RNAs (lncRNAs), on the way MYC is able to influence cellular transcriptome. To this aim we have intersected RNA-sequencing data f...
EGAD00001001441 | EGA
GenomicsMINCR is a MYC-induced lncRNA able to modulate MYC’s transcriptional network in Burkitt lymphoma cells
Despite the established role of the transcription factor MYC in cancer, little is known about the involvement of lncRNAs in mediating MYC’s function. Here we have intersected RNA-sequencing data from MYC-inducible cell lines, from a cohort of 91 mature B-cell lymphomas and from sorted germinal-cente...
EGAS00001001199 | EGA
GenomicsMMML associated cell line data
Data Access Committee EGAC00001000381
EGAC00001000381 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-17-08-2015-09:13:01:216-19 - samples
PAR-CLIP was performed on the Argonaute-2 protein (AGO2) in four lymphoma cell lines: Namalwa Raji SU-DHL-4 SU-DHL-6
EGAD00001001468 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-16-11-2015-13:05:39:993-4 - samples
Part of WGS seq data of Maligant Lymphoma study (ICGC)
EGAD00001001673 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-16-09-2015-13:05:30:578-414 - samples
After overexpression and knockdown of both described novel miRs nmiR-1 and nmiR-2 in BL cell lines (SU-DHL4 for nmiR-1 and Raji for nmiR-2), we performed regular RNA-Seq (including Mock controls for all cell lines) to identify their direct and indirect downstream mRNA targets.
EGAD00001001612 | EGA
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