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TranscriptomicsGene expression profiling of liver from C57BLKS/J and db/db 8 mice with an AAV harboring a control or GAbpa-specific miRNA under the LP1 promoter
To initially determine changes on the transcriptome level that might account for the phenotypic observations in an unbiased fashion, we performed large-scale mRNA expression profiling 8 weeks after treatment with an AAV harboring a control or GAbpa-specific miRNA under the LP1 promoter. Mice were su...
ORGANISM(S): Mus musculus 
2017-05-31 | E-MTAB-5775 | biostudies-arrayexpress
GenomicsChIP-Seq of Gabpa in male C57Bl/6 mice liver
To determine genomic sites of direct GAbpα recruitment in male C57Bl/6 mice liver tissue, we performed a cistrome analysis by chromatin immunoprecipitation using a GAbpα-specific antibody followed by massive parallel DNA sequencing (ChIP-Seq).
ORGANISM(S): Mus musculus 
2017-06-29 | E-MTAB-5831 | biostudies-arrayexpress
TranscriptomicsCo-activator function of RIP140 for NFκB/p65-dependent cytokine gene
High- and low-grade inflammatory responses represent a hallmark of numerous pathologies such as sepsis and bacterial infection or insulin resistance and obesity, respectively. Here we describe an unexpected co-activator function of receptor interacting protein (RIP) 140 for nuclear factor (NF) kB, a...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-10386 | biostudies-arrayexpress
TranscriptomicsTranscriptional co-factor TBLR1 controls lipid mobilization in white adipose tissue
Lipid mobilization (lipolysis) in white adipose tissue (WAT) critically controls lipid turnover and adiposity in humans. While the acute regulation of lipolysis has been studied in detail, the transcriptional determinants of WAT lipolytic activity remain still largely unexplored. Here we show that ...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-43658 | biostudies-arrayexpress
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