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TranscriptomicsINTERLEUKIN 15-DEPENDENT T CELL-LIKE INNATE INTRAEPITHELIAL LYMPHOCYTES DEVELOP IN THE INTESTINE AND TRANSFORM INTO LYMPHOMAS IN CELIAC DISEASE
The nature of gut intraepithelial lymphocytes lacking antigen receptors remains controversial. Herein we showed that, in humans and in mice, innate intestinal intraepithelial lymphocytes expressing intracellular CD3 (iCD3+ innate IELs) differentiate along an Id2 transcription factor (TF)-independent...
ORGANISM(S): Homo sapiens 
2016-11-23 | E-MTAB-4960 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis strain with T-DNA insertions in the HAF2 gene
T-DNA insertions in the HAF2 gene are characterised. The mutation of the gene induced production of pale young leaves. Genetic analysis showed that HAF2 is required for both phytochrome and cryptochrome signalling. Accordingly, light-inducible gene expression and CAB2 promoter activity were affected...
ORGANISM(S): Arabidopsis thaliana 
2004-10-05 | E-MEXP-178 | biostudies-arrayexpress
ProteomicsA single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients
Natalizumab (NZM), a humanized monoclonal IgG4 antibody to α4 integrins, is used to treat patients with relapsing-remitting multiple sclerosis (MS), but in about 6% of the cases persistent neutralizing anti-drug antibodies (ADAs) are induced leading to therapy discontinuation. To understand the basi...
ORGANISM(S): Homo sapiens (Human) 
2019-10-10 | PXD013599 | Pride
Antibody therapy Mhc-ii peptidomics Multiple sclerosis Human 
ProteomicsUnveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling
The development of ribosomal profiling (Riboseq) revealed the immense coding capacity of human and viral genomes. Here, we used Riboseq to delineate the translatome of HIV-1 in infected CD4+ T cells. In addition to canonical viral protein coding sequences (CDSs), we identify 98 alternative open read...
ORGANISM(S): Homo sapiens (Human) 
2025-01-15 | PXD043984 | Pride
Hiv-1 Ribosome profiling Immunopeptidome 
UnknownT-World: A highly general computational model of a human ventricular myocyte.
Not available
S-EPMC11974879 | biostudies-literature
GenomicsSite- and allele-specific de-silencing of polycomb repressive activity by insertional oncogenesis: a new recurrent mechanism of TAL1 activation in T-ALL
T-cell acute lymphoblastic leukemia’s (T-ALL) are malignant proliferations of thymocytes occurring through a large diversity of genomic and epigenetic alteration. TAL1 is amongst the most frequently deregulated oncogenes. Known TAL1 dysregulation mechanisms consist of t(1;14) translocations and SIL...
ORGANISM(S): Homo sapiens 
2014-07-10 | E-GEOD-59257 | biostudies-arrayexpress
ProteomicsFBXO7 Binds to and Increases the Expression of the p105 Subunit of NF-kB
Cell lysate from HAP1 cells were separated on several columns, the proteins were digested with trypsin and analysed on a Q Exactive HF-X instrument.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-08-05 | MSV000085912 | MassIVE
TranscriptomicsTranscription profiling of intraepithelial and peripheral CTL from patients with celiac disease or cytomegalovirus seropositive patients suggest that a stepwise transformation of CTLs into NK-like cells may underlie immunopathology in various chronic infectious and inflammatory diseases.
Celiac disease is an intestinal inflammatory disorder induced by dietary gluten in genetically susceptible individuals. The mechanisms underlying the massive expansion of interferon g–producing intraepithelial cytotoxic T lymphocytes (CTLs) and the destruction of the epithelial cells lining the sm...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4592 | biostudies-arrayexpress
UnknownInducible chromatin priming is associated with the establishment of immunological memory in T cells.
Not available
S-EPMC4772849 | biostudies-literature
ProteomicsNitrogen-fixation in the widely distributed model marine γ-proteobacterial diazotroph Candidatus Thalassolituus haligoni
The global significance of marine non-cyanobacterial diazotrophs, notably heterotrophic bacterial diazotrophs (HBDs), has become increasingly clear. Understanding N2 fixation rates for these largely uncultured organisms poses a challenge due to uncertain growth requirements and complex nitrogenase r...
ORGANISM(S): environmental samples <g-proteobacteria 
2024-08-10 | PXD045743 | Pride
Nitrogen-fixation Diazotroph Candidatus thalassolituus haligoni Proteome 
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