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TranscriptomicsWhole DNA methylome profiling in mice exposed to secondhand smoke
A large body of evidence has linked secondhand smoke (SHS) to lung cancer in nonsmokers. Yet, the underlying mechanisms of SHS carcinogenicity in nonsmokers' lung cancer remain elusive. Recently, we have demonstrated a genotoxic mode of action for SHS, based on the ability of this carcinogen to indu...
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-41421 | biostudies-arrayexpress
TranscriptomicsInvestigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells
Global loss of DNA methylation and locus/gene-specific gain of DNA methylation are two distinct hallmarks of carcinogenesis. Aberrant DNA methylation is implicated in smoking-related lung cancer. In this study, we have comprehensively investigated the modulation of DNA methylation consequent to chro...
ORGANISM(S): Homo sapiens 
2010-04-29 | E-GEOD-21532 | biostudies-arrayexpress
TranscriptomicsMammalian cells acquire epigenetic hallmarks of human cancer during immortalization
Progression to malignancy requires cells to overcome senescence and switch to an immortal phenotype. Thus, exploring the genetic and epigenetic changes that occur during senescence/immortalization may help elucidate crucial events that lead to cell transformation. In the present study, we have globa...
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-39034 | biostudies-arrayexpress
TranscriptomicsAlterations of methylome and transcriptome in human melanoma: the inverse relationship between epigenome integrity and BRAF mutation
Melanoma is the deadliest form of skin cancer with rising incidence and mortality rates. Oncogenic mutation in BRAF gene is the single most frequent genetic alteration in human melanoma; however, this event per se is not sufficient to produce melanoma in vivo. We have investigated whether epigenetic...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-31879 | biostudies-arrayexpress
UnknownAlterations of methylome and transcriptome in human melanoma: the inverse relationship between epigenome integrity and BRAF mutation
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-31879 | biostudies-other
TranscriptomicsAlterations of DNA methylome during chemical carcinogenesis
Similar to other genotoxic polycyclic aromatic hydrocarbons (PAHs), benzo[a]pyrene (BaP) is known to produce stable DNA adducts and other DNA damage. BaP is a powerful carcinogen and can induce tumors in the accessory sex organs (including prostate) of rodents. In the present study, we have invest...
ORGANISM(S): Mus musculus 
2013-06-30 | E-GEOD-41422 | biostudies-arrayexpress
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