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TranscriptomicsEffect of phenobarbital on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis
The nuclear receptors CAR (constitutive androstane receptor) and PXR (pregnane X receptor) mediate the effects of phenobarbital (PB) on gene transcription. To investigate the relative role of CAR and PXR in the induction response, cDNA arrays were generated containing 120 genes which are known to b...
ORGANISM(S): Mus musculus 
2008-08-23 | E-GEOD-12489 | biostudies-arrayexpress
TranscriptomicsIntegrated mutation, copy number and expression profiling in resectable non-small cell lung cancer
Study aims: to identify critical genes involved in non-small cell lung cancer (NSCLC) pathogenesis that may lead to a more complete understanding of this disease and identify novel molecular targets for use in the development of more effective therapies. Methods: Both transcriptional and genomic pro...
ORGANISM(S): Homo sapiens 
2010-11-27 | E-GEOD-25326 | biostudies-arrayexpress
TranscriptomicsFibrotic Myofibroblasts Manifest Genome-Wide Derangements of Translational Control
As a group, fibroproliferative disorders of the lung, liver, kidney, heart, vasculature and integument are common, progressive and refractory to therapy. They can emerge following toxic insults, but are frequently idiopathic. Their enigmatic propensity to resist therapy and progress to organ failure...
ORGANISM(S): Homo sapiens 
2008-11-20 | E-GEOD-11196 | biostudies-arrayexpress
GenomicsActive Promoters give rise to false positive 'Phantom Peaks' in ChIP-Seq experiments
We applied ChIP-seq to map the chromosomal binding sites for two nucleosome remodeling complexes containing the ATPase ISWI, ACF and RSF, in Drosophila embryos. Employing a panel of polyclonal and monoclonal antibodies directed against their signature subunits, ACF1 and RSF1, robust profiles were ob...
ORGANISM(S): Drosophila melanogaster 
2015-07-10 | E-GEOD-67323 | biostudies-arrayexpress
TranscriptomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-chip
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20529 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human carcinoma in situs cells from testis compared to fetal gonocytes, oogonia and cultured embryonic stem cells
Abstract: Testicular cancers in young adult men derive from an inborn precursor lesion, called carcinoma in situ (CIS) of the testis. CIS cells are believed to arise from primordial germ cells or gonocytes that fail to differentiate into the male germ cell lineage, and show a remarkable resemblance ...
ORGANISM(S): Homo sapiens 
2009-06-15 | E-TABM-488 | biostudies-arrayexpress
TranscriptomicsSingle cell derived clonal analysis of human glioblastoma links functional and genomic heterogeneity
Single cell derived clones were extracted from four glioblastoma tumors using fluorescence activated cell sorting with CD15 and CD133 markers. Unsorted bulk tumors were also derived. Gene expression analysis of clones of tumor GBM-482 involved comparison between TMZ resistant (n=5) and sensitive (n=...
ORGANISM(S): Homo sapiens 
2015-01-03 | E-MTAB-2693 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C57/BL6J mice at various ages post partum vs a common control adult (8 week) testis RNA from the same strain
Testis RNA from C57/BL6J mice at various ages post partum was compared to a common control consisting of adult (8 week) testis RNA from the same strain. This generates a time course showing the activation of genes on the array across the first wave of spermatogenesis, which can then be correlated w...
ORGANISM(S): Mus musculus 
2004-03-02 | E-MEXP-35 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human esophageal cancer samples
To compare gene expression profiles between normal, Barrett's Esophagus, ADC and SCC samples.
ORGANISM(S): Homo sapiens 
2007-01-31 | E-MEXP-692 | biostudies-arrayexpress
GenomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-Seq
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20530 | biostudies-arrayexpress
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