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MetabolomicsMetabolomic Profiles of Pancreatic β-Cells and Islets Exposed to Arsenic, part I β-Cells
Not available
ORGANISM(S): Mus musculus 
ST001266 | MetabolomicsWorkbench
MetabolomicsMetabolic profilings of rat INS-1 β-cells under changing levels of essential amino acids

Application of mass spectrometry enables the detection of metabolic differences between organisms with different nutritional settings. Divergence in the metabolic fingerprints of rat pancreatic INS-1 β-cells were systematically captured with regard to 10 individual essential amino acid (EAA) avai...

2022-05-24 | MTBLS3963 | MetaboLights
MetabolomicsMetabolomic Profiles of Pancreatic β-Cells and Islets Exposed to Arsenic, Islets (part-II)
Not available
ORGANISM(S): Mus musculus 
ST001314 | MetabolomicsWorkbench
GenomicsHNF4A-binding sites in HepG2 hepatoblastoma cells treated with TGF-beta
Specific regulation of target genes by transforming growth factor-β (TGF-β) in a given cellular context is determined in part by transcription factors and cofactors that interact with the Smad complex. In the present study, we determined Smad2 and Smad3 (Smad2/3) binding regions in the promoters of ...
ORGANISM(S): Homo sapiens 
2011-06-08 | E-GEOD-28845 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of human pancreatic beta cells
Outline: using label-free alternate-scanning LC-MS/MS, we compared the proteomic architecture of core functional pathways in pancreatic beta cells of human origin. Results: we quantified the relative molar abundance of 707 proteins mainly composed of functional pathways of metabolism, protein synthe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-31 | MSV000082882 | MassIVE
TranscriptomicsIdentification of beta-catenin-associated RNAs in myeloid leukaemia cells through RIP-seq
Myeloid cell lines (K562 and HEL) were treated overnight with CHIR99021 or a vehicle control (DMSO). CHIR99021 treatment inhibits GSK3B within the destruction complex functioning in Wnt/beta-catenin signalling pathway, thereby preventing beta-catenin degradation and promoting its stabilization. Foll...
ORGANISM(S): Homo sapiens 
2025-04-08 | E-MTAB-14675 | biostudies-arrayexpress
ProteomicsIdentification of β-Catenin-Interacting Proteins in Nuclei of Aquaporin-2-Expressing Rat Collecting Duct Cells
The gene encoding the aquaporin-2 water channel is regulated transcriptionally in response to vasopressin. In the renal collecting duct, vasopressin stimulates the nuclear translocation and phosphorylation (at Ser552) of β-catenin, a multifunctional protein that can act as a transcriptional co-regul...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD005792 | Pride
Transcription Transcriptional co-regulator Aquaporin-2 Kidney 
ProteomicsSARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment
Emerging evidence points towards an intricate relationship between the pandemic coronavirus disease 2019 (COVID-19) and diabetes. While diabetes is associated with an increased risk of severe COVID-19, new-onset type 1 diabetes (T1D) has been observed in COVID-19 patients, convoluting diabetes as bo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-07-24 | PXD025629 | Pride
Pancreas Beta-cells Sars-cov-2 Human 
ProteomicsDiabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secrete adequate levels of insulin. The molecular mechanisms underlying the progressive failure of β-cells to respond to glucose in type-2 diabetes remain unresolved. Using a combination of transcriptomics...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-10 | PXD012979 | Pride
Pancreas Islets Diabetes Β-cells 
TranscriptomicsNeonatal beta cells lack the specialized metabolic phenotype of mature beta cells
Fetal and neonatal beta cells have poor glucose-induced insulin secretion and only gain robust glucose responsiveness several weeks after birth. This unresponsiveness may be due to a generalized immaturity of the metabolic pathways normally found in beta cells. Gene expression profile of neonatal (1...
ORGANISM(S): Rattus norvegicus 
2011-02-22 | E-GEOD-24790 | biostudies-arrayexpress
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