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While nearly comprehensive proteome coverage can be achieved from bulk tissue or cultured cells, the data usually lacks spatial resolution. As a result, tissue based proteomics averages protein abundance across multiple cell types and/or localisations. With proteomics platforms lacking sensitivity a...
ORGANISM(S): Homo sapiens (Human) 
2019-03-04 | PXD012101 | Pride
Acute myeloid leukemia (AML) remains a cancer with dismal prognosis, particularly in high-risk disease patients and those ineligible for allogeneic stem cell transplantation. BCL-2 inhibitor venetoclax, in combination with hypomethylating agents, has emerged as an effective therapy and forms the bac...
ORGANISM(S): Homo sapiens 
Acute myeloid leukemia (AML) is a highly heterogeneous disease consisting of different cell states that drive therapy resistance. We aimed to transcriptionally characterize AML subpopulations from patients treated with standard chemotherapy or BCL-2 inhibitor Venetoclax. We used CD64 and CD11b expre...
ORGANISM(S): Homo sapiens 
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