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TranscriptomicsTranscriptome signature of mouse embryonic stem cell-derived microglia is closely related to primary cultured microglia
Preparation of primary microglial cultures from postnatal mice is tedious with a low yield, high variability and risk of astrocytic contamination. Microglia derived from embryonic stem cells (ESdM) have been suggested as alternative source, but it is unclear how closely ESdM resemble the molecular p...
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-43808 | biostudies-arrayexpress
TranscriptomicsApplication of blood transcriptomics to identify three novel biomarkers for monitoring anti-TGFbeta therapy
Background: Development of target specific therapeutics greatly benefits from simultaneous identification of biomarkers to determine aspects of bioactivity, drug safety and efficacy or even treatment outcome. This is particularly important when targeting pleiotropic factors such as the TGFbeta syste...
ORGANISM(S): Homo sapiens 
2010-07-20 | E-GEOD-15468 | biostudies-arrayexpress
TranscriptomicsTranscriptome wide analysis of untreated, classically and alternatively activated macrophages
Analysis of human M0-, M1-, and M2-like macrophages. Total RNA was isolated from untreated, classically and aternative activated human macrophages
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-35449 | biostudies-arrayexpress
TranscriptomicsTranscriptome wide analysis of classically and alternatively activated macrophages
Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare NGS-derived human M1- and M2-like macrophage profiling (RNA-seq) to microarray and quantitative reverse transcription polymerase chain reaction (qRT–PCR) methods an...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-36952 | biostudies-arrayexpress
TranscriptomicsEpigenomic landscapes of human inflammation associated macrophages [RNA-seq]
We previously demonstrated by genomic and bioinformatical approaches that human macrophage (MΦ) activation is best described by a spectrum model (Xue et al, Immunity, 2014). MΦ integrate exogenous input signals on transcriptional level in a unique fashion to generate specific functional programs, ...
ORGANISM(S): Homo sapiens 
2016-02-28 | E-GEOD-66593 | biostudies-arrayexpress
TranscriptomicsDifferentiation and specification of resident tissue macrophages [MARS-seq]
Tissue resident macrophages are functionally diverse cells that share an embryonic mesodermal origin. However, the mechanism(s) that control their specification remain unclear. We performed transcriptional, molecular and in situ spatio-temporal analyses of macrophage development in mice. We report t...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-81760 | biostudies-arrayexpress
TranscriptomicsDifferentiation and specification of resident tissue macrophages [SMART-Seq2]
Tissue resident macrophages are functionally diverse cells that share an embryonic mesodermal origin. However, the mechanism(s) that control their specification remain unclear. We performed transcriptional, molecular and in situ spatio-temporal analyses of macrophage development in mice. We report t...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-81686 | biostudies-arrayexpress
TranscriptomicsDifferentiation and specification of resident tissue macrophages [ID3-KO RNA-seq]
Tissue resident macrophages are functionally diverse cells that share an embryonic mesodermal origin. However, the mechanism(s) that control their specification remain unclear. We performed transcriptional, molecular and in situ spatio-temporal analyses of macrophage development in mice. We report t...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-83854 | biostudies-arrayexpress
GenomicsEpigenomic landscapes of human inflammation associated macrophages [ChIP-seq]
We previously demonstrated by genomic and bioinformatical approaches that human macrophage (MΦ) activation is best described by a spectrum model (Xue et al, Immunity, 2014). MΦ integrate exogenous input signals on transcriptional level in a unique fashion to generate specific functional programs, ...
ORGANISM(S): Homo sapiens 
2016-02-28 | E-GEOD-66594 | biostudies-arrayexpress
UnknownRivaroxaban vs Vitamin K Antagonist in Patients With Atrial Fibrillation and Advanced Chronic Kidney Disease.
Not available
S-EPMC11198259 | biostudies-literature
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