Sort   by:  
 Page size 
Transcriptomicsp53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo
The goal of the present study was to compare hepatic toxicogenomic signatures across in vitro and in vivo mouse models following exposure to acetaminophen (APAP) or its relatively nontoxic regioisomer 3'-hydroxyacetanilide (AMAP). Two different Affymetrix microarray platforms and one Agilent Oligonu...
ORGANISM(S): Mus musculus 
2016-03-29 | E-GEOD-56576 | biostudies-arrayexpress
TranscriptomicsDifferential Regulation of Mitogen-Activated Protein Kinases by Acetaminophen in TAMH cells
Acetaminophen (APAP), a widely used analgesic and antipyretic that is considered to be relatively safe at recommended doses, is the leading cause of drug-induced liver failure in the United States. 3M-bM-^@M-^Y-Hydroxyacetanilide (AMAP), a regioisomer of acetaminophen is useful as a comparative too...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-18614 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses
Domoic acid (DA) is a neuroexcitatory amino acid that is naturally produced by some marine diatom species of the genus Pseudo-nitzschia. Ingestion of DA-contaminated seafood by humans results in a severe neurotoxic disease known as amnesic shellfish poisoning (ASP). Clinical signs of ASP include s...
ORGANISM(S): Danio rerio 
2009-07-06 | E-GEOD-12140 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells from healthy volunteers exposed to diesel exhaust inhalation
Background: Diesel exhaust (DE) is the primary source of urban fine particulate matter, which has been associated with cardiovascular disease in epidemiological studies. These effects may be related to oxidative stress and systemic inflammation with resulting perturbation of vascular homeostasis. Pe...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7462 | biostudies-arrayexpress
TranscriptomicsEffects of neonatal stress and morphine on murine hippocampal gene expression
Critically ill preterm infants experience multiple stressors while hospitalized. Morphine is commonly prescribed to ameliorate their pain and stress. We hypothesized that neonatal stress will have a dose-dependent effect on hippocampal gene expression, and these effects will be altered by morphine t...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-50382 | biostudies-arrayexpress
TranscriptomicsTbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex
Areas and layers of the cerebral cortex are specified by genetic programs that are initiated in progenitor cells and then, implemented in postmitotic neurons. Here, we report that Tbr1, a transcription factor expressed in postmitotic projection neurons, exerts positive and negative control over both...
ORGANISM(S): Mus musculus 
2010-07-27 | E-GEOD-22371 | biostudies-arrayexpress
TranscriptomicsCopper-induced deregulation of microRNA expression in the zebrafish olfactory system
Although environmental trace metals, such as copper (Cu), can disrupt normal olfactory function in fish, the underlying molecular mechanisms of metal-induced olfactory injury have not been elucidated. Current research has suggested the involvement of epigenetic modifications. To address this hypothe...
ORGANISM(S): Danio rerio 
2014-04-30 | E-GEOD-46891 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of high-dose recombinant erythropoietin treatment of unilateral brain injury in neonatal mouse hippocampus
Comparison of gene expression in the hippocampus of 10 day old sham-injured and brain-injured BALB-c mice, and examine the effects of high dose Epo on these conditions at 24 hours following injury. Four groups of six mice were treated with epo/no epo, injured/not injured.
ORGANISM(S): Mus musculus 
2015-12-11 | E-GEOD-75865 | biostudies-arrayexpress
TranscriptomicsTranscriptional impact of organophosphate and metal mixtures on olfaction: copper dominates the chlorpyrifos-induced response in adult zebrafish.
Chemical exposures in fish have been linked to loss of olfaction leading to an inability to detect predators and prey and decreased survival. However, the mechanisms underlying olfactory neurotoxicity are not well characterized, especially in environmental exposures which involve chemical mixtures. ...
ORGANISM(S): Danio rerio 
2013-05-21 | E-GEOD-47039 | biostudies-arrayexpress
TranscriptomicsChoriodecidual Infection Downregulates Angiogenesis and Morphogenesis Pathways in Fetal Lungs from Macaca Nemestrina
Intrauterine exposure to amniotic fluid (AF) cytokines is thought to predispose to bronchopulmonary dysplasia (BPD). We evaluated the effects of GBS exposure on RNA expression in fetal lung tissue to determine early molecular pathways associated with fetal lung injury that may progress to BPD. Ten ...
ORGANISM(S): Macaca nemestrina 
2013-04-23 | E-GEOD-39029 | biostudies-arrayexpress
Sort   by:  
 Page size